NBPF15
Identifiers
Aliases	NBPF15, AB14, AG3, NBPF16, neuroblastoma breakpoint family member 15, NBPF member 15, MGC8902
External IDs	OMIM:610414,614005;HomoloGene:41035;GeneCards:NBPF15;OMA:NBPF15 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.1 Start 144,421,386bp[1] End 144,461,674bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cerebellar hemisphere thymus right hemisphere of cerebellum stromal cell of endometrium thyroid gland ganglionic eminence right lobe of thyroid gland left lobe of thyroid gland right lobe of liver n/a More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 284565 n/a Ensembl ENSG00000266338 n/a UniProt Q8N660 n/a RefSeq (mRNA) NM_001102663 NM_001170755 NM_173638 n/a RefSeq (protein) NP_001164226 NP_775909 n/a Location (UCSC) Chr 1: 144.42 – 144.46 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Neuroblastoma breakpoint family, member 15, also known asNBPF15, is aprotein which in humans is encoded by theNBPF15gene.^[3] The gene is 18762 bp long, withmRNA that is 3837 bp long. The gene is located on chromosome 1q21.1. Its sub-cellular location is predicted to be in thenucleus andcytoplasm.^[4] It contains what is known as theNBPF repeat, which is a two-exon stretch of sequence that is characteristic of all 21 members of the NBPF gene family. The repeat is considered the ancestral exons, and the NBPF family has been linked to primate evolution.^[5]

The function of NBPF16 is not fully understood. It is a member of the NBPF family of proteins, which have been linked to possible roles inoncogenesis andtumor suppressor genes.^[5]

The protein is composed of 670amino acids. The gene contains five domains of unknown function, calledDUF1220. DUF1220 domains are found in all members of the NBPF gene family, although the number differs between each member. Repetitive structure with high intergenic and intragenic sequence conservation, both in coding and noncoding regions. Makes it possible for homologous recombination to occur easily between different alleles. The repetitiveness of it, and the other members of the NBPF gene family is thought to have arisen from segmental duplications on chromosome 1.^[5]

Properties of NBPF16 that were predicted usingbioinformatics tools:

• Molecular weight: 76 kD^[6]
• Isoelectric point: 4.43^[7]
• Post-translational modification: none predicted.
• No predictedsignal peptide or signal peptide cleavage site.^[8]
• No interacting proteins or binding partners.

There is little to no expression data available for the gene, but most indications point to it being ubiquitously expressed throughout the body.

There exists no greatorthologs outside of primates. These orthologs were gathered from BLAT.^[9] and BLAST searches^[10]

Due to there being 21 other members of the NBPF gene family, there are 21paralogs of NBPF16. They all show high conservation and repetitive structures.

• August 2006, Ker Than 31 (31 August 2006)."Brain Gene May Help Make Us Human".livescience.com. Retrieved23 April 2020.{{cite web}}: CS1 maint: numeric names: authors list (link)

• Genes on human chromosome 1
• Human proteins

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