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N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline

From Wikipedia, the free encyclopedia
N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline[1]
Names
Preferred IUPAC name
Ethyl 2-ethoxyquinoline-1(2H)-carboxylate
Other names
Ethyl 1,2-dihydro-2-ethoxyquinoline-1-carboxylate
Identifiers
3D model (JSmol)
AbbreviationsEEDQ
ChEMBL
ChemSpider
ECHA InfoCard100.036.728Edit this at Wikidata
EC Number
  • 240-418-2
UNII
  • InChI=1S/C14H17NO3/c1-3-17-13-10-9-11-7-5-6-8-12(11)15(13)14(16)18-4-2/h5-10,13H,3-4H2,1-2H3
    Key: GKQLYSROISKDLL-UHFFFAOYSA-N
  • CCOC1C=CC2=CC=CC=C2N1C(=O)OCC
Properties
C14H17NO3
Molar mass247.29 g/mol
Melting point62 to 67 °C (144 to 153 °F; 335 to 340 K)
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
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Chemical compound

N-Ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) is an irreversible dopamine-receptor antagonist.[2]

EEDQ is also a highly specific reagent for carboxyl groups. It enables the coupling of acylamino acids with amino acid esters in high yield and without racemization.[3]

It is also an irreversibledopamine transporter (DAT)blockerin vitro, though it is ineffectivein vivo.[4]

References

[edit]
  1. ^2-Ethoxy-1-ethoxycarbonyl-1,2-dihydroquinoline atSigma-Aldrich
  2. ^Neuroscience Letters 1992, 137(2), p.265
  3. ^https://www.bachem.com/
  4. ^Tarazi FI, Kula NS, Zhang K, Baldessarini RJ (August 2000). "Alkylation of rat dopamine transporters and blockade of dopamine uptake by EEDQ".Neuropharmacology.39 (11):2133–8.doi:10.1016/s0028-3908(00)00047-2.PMID 10963756.
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists


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