Inenzymology, amyosin-heavy-chain kinase (EC2.7.11.7) is anenzyme thatcatalyzes thechemical reaction

ATP + [myosin heavy-chain]${\displaystyle \rightleftharpoons }$ ADP + [myosin heavy-chain] phosphate

Thus, the twosubstrates of this enzyme areATP andmyosin heavy-chain, whereas its twoproducts areADP andmyosin heavy-chain phosphate.

This enzyme belongs to the family oftransferases, specifically those transferring a phosphate group to the sidechainoxygen atom ofserine orthreonine residues inproteins (protein-serine/threonine kinases). Thesystematic name of this enzyme class isATP:[myosin heavy-chain] O-phosphotransferase. Other names in common use include

• ATP:myosin-heavy-chain O-phosphotransferase
• calmodulin-dependent myosin heavy chain kinase
• MHCK
• MIHC kinase
• myosin heavy chain kinase
• myosin I heavy-chain kinase
• myosin II heavy-chain kinase
• [myosin-heavy-chain] kinase
• myosin heavy chain kinase A
• STK6.

• Cote GP, Bukiejko U (1987)."Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum".J. Biol. Chem.262 (3):1065–72.doi:10.1016/S0021-9258(19)75750-0.PMID 3027076.
• Hammer JA III, Albanesi JP, Korn ED (1983)."Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii".J. Biol. Chem.258 (16):10168–75.doi:10.1016/S0021-9258(17)44620-5.PMID 6309772.
• Rieker JP, Swanljung-Collins H, Collins JH (1987)."Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border".J. Biol. Chem.262 (31):15262–8.doi:10.1016/S0021-9258(18)48169-0.PMID 2822719.
• Ravid S, Spudich JA (1989)."Myosin heavy chain kinase from developed Dictyostelium cells Purification and characterization".J. Biol. Chem.264 (25):15144–50.doi:10.1016/S0021-9258(18)63823-2.PMID 2549052.
• Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED (1990)."Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides".J. Biol. Chem.265 (27):16138–44.doi:10.1016/S0021-9258(17)46199-0.PMID 2168881.
• Ravid S, Spudich JA (1992)."Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family".Proc. Natl. Acad. Sci. U.S.A.89 (13):5877–81.Bibcode:1992PNAS...89.5877R.doi:10.1073/pnas.89.13.5877.PMC 49400.PMID 1321427.
• Futey LM, Medley QG, Cote GP, Egelhoff TT (1995)."Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins".J. Biol. Chem.270 (2):523–9.doi:10.1074/jbc.270.2.523.PMID 7822274.
• Korn ED, Brzeska H (1998)."Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase".Proc. Natl. Acad. Sci. U.S.A.95 (8):4146–51.Bibcode:1998PNAS...95.4146S.doi:10.1073/pnas.95.8.4146.PMC 22456.PMID 9539704.
• Egelhoff TT, Croft D, Steimle PA (2005)."Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly".J. Biol. Chem.280 (4):2879–87.doi:10.1074/jbc.M410803200.PMID 15545285.

ThisEC 2.7enzyme-related article is astub. You can help Wikipedia byexpanding it.

• v
• t
• e

• EC 2.7.11
• Enzymes of unknown structure
• EC 2.7 stubs

• Articles with short description
• Short description matches Wikidata
• All stub articles