-2-amino-3-(4-hydroxy-3-iodophenyl)propanoic_acid_200.svg) | |
 3-Iodo-L-tyrosine | |
| Names | |
|---|---|
| IUPAC name (2S)-2-Amino-3-(4-hydroxy-3-iodophenyl)propanoic acid | |
| Other names Monoiodotyrosine; MIT[1] | |
| Identifiers | |
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3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
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| DrugBank |
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| ECHA InfoCard | 100.000.677 |
| MeSH | Monoiodotyrosine |
| UNII | |
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| Properties | |
| C9H10INO3 | |
| Molar mass | 307.087 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
3-Iodotyrosine is an intermediate in the synthesis ofthyroid hormones which is derived fromiodination oftyrosine at themeta-position of thebenzene ring. One unit can combine withdiiodotyrosine to formtriiodothyronine, as occurs in thecolloid of thethyroid follicle. Two units can combine to form3,3'-diiodothyronine.
3-Iodotyrosine is areversibleinhibitor of theenzymetyrosine hydroxylase.[2]
3-Iodotyrosine, a pathway inhibitor in the synthesis of the neurotransmitterdopamine, was used to determine the effects of decreased dopamine levels in social spacing ofDrosophila melanogaster. 3-4 day old flies that were fed 3-iodotyrosine for 24 hours were shown to have altered dopamine levels.[3]
