Monoamine-depleting agents are a group ofdrugs which reversibly deplete one or more of themonoamine neurotransmitters – serotonin,dopamine, andnorepinephrine.[1][2] Onemechanism by which these agents act is byinhibitingreuptake by thevesicular monoamine transporters,VMAT1 andVMAT2.[2][3] Examples of monoamine-depleting agents includedeutetrabenazine,methyldopa,oxypertine,reserpine,tetrabenazine,[4] andvalbenazine.[1][2][3] Tetrabenazine selectively depletes dopamine at low doses and is used as ananimal model ofamotivation.[5][6]
Monoamine synthesis inhibitors, such as thetryptophan hydroxylaseinhibitor and serotonin synthesis inhibitorpara-chlorophenylalanine (PCPA or fenclonine), also act as monoamine-depleting agents, as do various other agents, for instancemonoaminergic neurotoxins.[7]
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