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Mizolastine

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
Mizolastine
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth (tablets)
ATC code
Legal status
Legal status
Identifiers
  • 2-[{1-[1-(4-Fluorobenzyl)-1H-benzimidazol-2-yl]piperidin-4-yl}(methyl)amino]pyrimidin-4(1H)-one
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.149.406Edit this at Wikidata
Chemical and physical data
FormulaC24H25FN6O
Molar mass432.503 g·mol−1
3D model (JSmol)
  • CN(C1CCN(CC1)C2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)C5=NC=CC(=O)N5
  • InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,14-16H2,1H3,(H,26,28,32) ☒N
  • Key:PVLJETXTTWAYEW-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Mizolastine (Mizollen) is a once-daily, non-sedatingantihistamine. It blocksH1 receptors and is commonly fast-acting.[1] It does not prevent the actual release of histamine frommast cells, it only prevents histamine from binding to receptors. Side effects can include dry mouth and throat.[2]

References

[edit]
  1. ^Simons FE (March 1999). "Mizolastine: antihistaminic activity from preclinical data to clinical evaluation".Clinical and Experimental Allergy.29 (Suppl 1):3–8.doi:10.1046/j.1365-2222.1999.00002.x.PMID 10209699.S2CID 616333.
  2. ^"MIZOLASTINE: British National Formulary". Retrieved2010-02-01.
Benzimidazoles(*)
Diarylmethanes
Ethylenediamines
Tricyclics
Others
Fortopical use
H1
Agonists
Antagonists
H2
Agonists
Antagonists
H3
Agonists
Antagonists
H4
Agonists
Antagonists


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