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Milacemide

From Wikipedia, the free encyclopedia
Milacemide
Skeletal formula of milacemide
Skeletal formula of milacemide
Names
IUPAC name
N2-Pentylglycinamide
Systematic IUPAC name
2-(Pentylamino)acetamide[1]
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
MeSHmilacemide
UNII
  • InChI=1S/C7H16N2O/c1-2-3-4-5-9-6-7(8)10/h9H,2-6H2,1H3,(H2,8,10) checkY
    Key: GJNNXIYZWIZFRH-UHFFFAOYSA-N checkY
  • CCCCCNCC(N)=O
Properties
C7H16N2O
Molar mass144.218 g·mol−1
logP0.754
Related compounds
Related compounds
Tricine
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
Chemical compound

Milacemide (INN)[2] is anMAO-B inhibitor andglycineprodrug.[3] It has been studied for its effects on human memory and as a potential treatment for the symptoms ofAlzheimer's disease.[4] Early clinical trials did not show positive results however,[3] and the drug is now abandoned and it is sold as a nonprescription drug or supplement. While milacemide is not anamino-acid, it acts similarly toglycine in the brain.[5]

References

[edit]
  1. ^"milacemide - Compound Summary".PubChem Compound. USA: National Center for Biotechnology Information. 8 August 2005. Identifiers and Related Records. Retrieved9 January 2012.
  2. ^"International Nonproprietary Names for Pharmaceutical Substances. Supplement toWHO Chronicle, 1983, Vol. 37, No. 6 (December). Recommended International Nonproprietary Names (Rec. INN): List 23"(PDF). World Health Organization. p. 6. Retrieved8 January 2016.
  3. ^abDysken, MW; Mendels, J; LeWitt, P; Reisberg, B; Pomara, N; Wood, J; Skare, S; Fakouhi, JD; Herting, RL (May 1992). "Milacemide: a placebo-controlled study in senile dementia of the Alzheimer type".Journal of the American Geriatrics Society.40 (5):503–6.doi:10.1111/j.1532-5415.1992.tb02019.x.PMID 1634705.S2CID 34816755.
  4. ^Harris, Carol Turkington ; foreword by Joseph R. (2002).The encyclopedia of the brain and brain disorders (2nd ed.). New York, NY: Facts on File.ISBN 0-8160-4774-X. Archived fromthe original on 2014-03-03. Retrieved2017-09-10.{{cite book}}: CS1 maint: multiple names: authors list (link)
  5. ^Theodore I. Lidsky and Jay S. Schneider Phd, Brain Candy (2001).Brain Candy. New York, United States Of America: Simon & Schuster.ISBN 9780743218436.
Non-specific
AAADTooltip Aromatic L-amino acid decarboxylase
MAOTooltip Monoamine oxidase
Phenethylamines
(dopamine,epinephrine,
norepinephrine)
PAHTooltip Phenylalanine hydroxylase
THTooltip Tyrosine hydroxylase
DBHTooltip Dopamine beta-hydroxylase
PNMTTooltip Phenylethanolamine N-methyltransferase
COMTTooltip Catechol-O-methyl transferase
Tryptamines
(serotonin,melatonin)
TPHTooltip Tryptophan hydroxylase
AANATTooltip Serotonin N-acetyl transferase
ASMTTooltip Acetylserotonin O-methyltransferase
Histamine
HDCTooltip Histidine decarboxylase
HNMTTooltip Histamine N-methyltransferase
DAOTooltip Diamine oxidase
Receptor
(ligands)
GlyRTooltip Glycine receptor
NMDARTooltip N-Methyl-D-aspartate receptor
Transporter
(blockers)
GlyT1Tooltip Glycine transporter 1
GlyT2Tooltip Glycine transporter 2
AMPARTooltip α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor
KARTooltip Kainate receptor
NMDARTooltip N-Methyl-D-aspartate receptor


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