Epps' first on-screen appearance came inVin Diesel's second directorial film,Strays in 1997. In 1999, Epps was then cast asIce Cube's co-star in the sequel,Next Friday. This followed weeks of auditions, after Ice Cube attended a stand-up set Epps did, and then asked Epps to try out for the role of Day-Day Jones.[6]Later that year, Epps had a cameo in3 Strikes, and supportedJamie Foxx inBait.
Epps starred alongsideJordin Sparks andWhitney Houston in the 2012 remake ofSparkle, in his first non-comedic role as the main antagonist, Satin, a stand-up comic by day, an evil and abusive drug kingpin by night, who is engaged in an affair with the titular character's sister. Epps' performance was well received by critics and audiences. In 2014, Epps landed the coveted role ofRichard Pryor in a planned Pryor biopic to be directed byLee Daniels;[7][8] however, the project has remained indevelopment hell. Epps did portray Pryor in the 2016Nina Simone biopicNina and in an episode of theHBO drama seriesWinning Time about theL.A. Lakers.[9]
Epps also hostedG Unit's 2008 mixtapeElephant In The Sand, appearing on the track "Hollow Thru Him". Epps also has a song called "Big Girls", which came out in 2008. It was originally recorded byBow Wow featuringYung Joc. The song is currently oniTunes and can be found on his album,Funny Bidness: Da Album, which was released October 27, 2009. Epps also has featured in rapper French Montana'sMac Wit Da Cheese mixtape, which was released on April 19, 2009. Epps has also featured on theDom Kennedy song "Intro/Hard Work" on hisFutureStreet/DrugSounds mixtape.[10]
Part of his stand-up comedy inUnder Rated & Never Faded was sampled for the song "I'm On Everything" byBad Meets Evil on their first EP,Hell: The Sequel[11] and on the track "Runaway", fromJ. Cole's second albumBorn Sinner. Mike Epps was also known in his hometown of Indianapolis as the CEO of Naptown Records.[citation needed] In 2006 he signed local artist Philthyphil.[citation needed] This artist had just been released from prison after serving three years for a drug indictment in which he was the suspected distributor of large amounts of narcotics.[citation needed] The record deal which was reportedly worth $175,000 was later terminated after Phillip "Philthyphil" White was charged with first-degree murder in Oakland, CA in 2007.[12]
Epps served as the "Super Bowl ambassador" in his nativeIndianapolis for the2012 Super Bowl. He was featured in commercials promoting the Super Bowl Village and he made special appearances in the Village during the week of the Super Bowl.[15]
Epps has been criticized by disability campaigners for mocking physically and mentally disabled children in his stand-up act.[16]
On June 1, 2014, Epps purportedly assaulted fellow stand-up comedianLaVar Walker outside of the Uptown Comedy Club. It was stated Epps and two of his bodyguards did this in response to Walker making a parody video about Epps and comedianKevin Hart. Epps allegedly struck him in the face and kicked him in the stomach and back, while one of the other two men threw the victim's cellphone and crushed his prescription glasses. Atlanta Police issued a warrant for Epps' arrest two days later on June 3.[17]
Around mid-2017, Epps received controversy for bringing a kangaroo onto the stage during one of his shows. Many noted the animal looked distressed, with Epps grabbing and holding it against its will. Epps later apologized, saying it was completely unscripted and that he should have never hurt an animal.[18]