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| ECHA InfoCard | 100.000.230 |
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| Formula | C5H6N2OS |
| Molar mass | 142.18 g·mol−1 |
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Methylthiouracil is anorganosulfur compound that is used antithyroid preparation. It is athioamide, closely related topropylthiouracil. Methylthiouracil is not used clinically in the United States, it has a similar mechanism of action and side effect to that of propylthiouricil. The drug acts to decrease the formation of stored thyroid hormone, as thyroglobulin in the thyroid gland. The clinical effects of the drug to treat the hyperthyroid state can have a lag period of up to two weeks, depending on the stores of thyroglobulin and other factors.
Methylthiouracil is prepared quite simply by condensation ofethyl acetoacetate withthiourea.[2]
Further work in this series shows that better activity was obtained by incorporation of a lipophilic side chain.
