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Methylprednisolone succinate

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Chemical compound

Pharmaceutical compound
Methylprednisolone succinate
Chemical structure of methylprednisolone sodium succinate
orange capped glass vial of Solu-Medrol 125 mg
Molecular structure and glass vial preparation
Clinical data
Trade namesSolu-Medrol, Solu-Medrone, Urbason, others
Other namesMethylprednisolone hemisuccinate; 6α-Methylprednisolone 21-hemisuccinate
AHFS/Drugs.comMonograph
License data
Routes of
administration		Intravenous injection
Drug classCorticosteroid;Glucocorticoid
ATC code
Legal status
Legal status
Identifiers
  • 4-[2-[(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-6,10,13-trimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
CAS Number
PubChemCID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard(EPA)
ECHA InfoCard100.017.416Edit this at Wikidata
Chemical and physical data
FormulaC26H34O8
Molar mass474.550 g·mol−1
3D model (JSmol)
  • C[C@H]1C[C@H]2[C@@H]3CC[C@@]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)C=C4)C)O)C)(C(=O)COC(=O)CCC(=O)O)O
  • InChI=1S/C26H34O8/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31)/t14-,16-,17-,19-,23+,24-,25-,26-/m0/s1
  • Key:IMBXEJJVJRTNOW-XYMSELFBSA-N

Methylprednisolone succinate, sold under the brand nameSolu-Medrol among others, is asyntheticglucocorticoidcorticosteroid and acorticosteroid ester—specifically the C21succinateester ofmethylprednisolone—which is used byintravenous administration.[3][4] Methylprednisolone succinate is provided as two differentsalts when used as apharmaceutical drug: asodium salt (methylprednisolone sodium succinate; brand name Solu-Medrol, others) and ahydrogen salt (methylprednisolone hemisuccinate ormethylprednisolone hydrogen succinate; brand name Urbason).[3][4]

Methylprednisolone succinate was approved for medical use in the United States in 1959.[2]

References

[edit]
  1. ^"Solu-Medrol Product information".Health Canada. 3 February 2009. Retrieved19 April 2024.
  2. ^ab"Solu-Medrol- methylprednisolone sodium succinate injection, powder, for solution".DailyMed. 17 December 2021. Retrieved23 December 2023.
  3. ^abElks J (14 November 2014).The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 811–.ISBN 978-1-4757-2085-3.
  4. ^abIndex Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 675–.ISBN 978-3-88763-075-1.
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