| methylenetetrahydrofolate dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Methylenetetrahydrofolate dehydrogenase dimer, Human | |||||||||
| Identifiers | |||||||||
| EC no. | 1.5.1.5 | ||||||||
| CAS no. | 9029-14-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, amethylenetetrahydrofolate dehydrogenase (NADP+) (EC1.5.1.5) is anenzyme thatcatalyzes thechemical reaction
Thus, the twosubstrates of this enzyme are5,10-methylenetetrahydrofolate andNADP+, whereas its 3products are5,10-methenyltetrahydrofolate,NADPH, andH+.
This enzyme belongs to the family ofoxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. This enzyme participates inglyoxylate and dicarboxylate metabolism andone carbon pool by folate.
As of late 2007, 8structures have been solved for this class of enzymes, withPDB accession codes1A4I,1DIA,1DIB,1DIG,1LU9,1LUA,2C2X, and2C2Y.
Mutations of theMTHFD1 gene may disrupt the activity of the enzyme and causemethylenetetrahydrofolate dehydrogenase 1 deficiency, also known as combined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (CIMAH).
Thesystematic name of this enzyme class is5,10-methylenetetrahydrofolate:NADP+ oxidoreductase. Other names in common use includeN5,N10-methylenetetrahydrofolate dehydrogenase,5,10-methylenetetrahydrofolate:NADP oxidoreductase,5,10-methylenetetrahydrofolate dehydrogenase,methylenetetrahydrofolate dehydrogenase, andmethylenetetrahydrofolate dehydrogenase (NADP).
