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Methyldihydromorphine

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
Methyldihydromorphine
Clinical data
ATC code
  • none
Legal status
Legal status
Identifiers
  • (5α,6α)-6,17-Dimethyl-4,5-epoxymorphinan-3,6-diol
CAS Number
PubChemCID
ChemSpider
UNII
KEGG
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC18H23NO3
Molar mass301.386 g·mol−1
3D model (JSmol)
  • C[C@@]1(CC[C@H]2[C@H]3Cc4ccc(c5c4[C@]2([C@H]1O5)CCN3C)O)O
  • InChI=1S/C18H23NO3/c1-17(21)6-5-11-12-9-10-3-4-13(20)15-14(10)18(11,16(17)22-15)7-8-19(12)2/h3-4,11-12,16,20-21H,5-9H2,1-2H3/t11-,12+,16-,17-,18-/m0/s1 ☒N
  • Key:NBKVWIJQJMEQLE-NGTWOADLSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Methyldihydromorphine[2] is a semi-syntheticopioid originally developed in Germany in 1936, controlled under both domestic law and UN conventions because of its possible potential for abuse. Methyldihydromorphine is related toheterocodeine and is not a synonym fordihydrocodeine or dihydroheterocodeine (6-methoxydihydromorphine).

This compound is a derivative ofhydromorphone[3] It has been found to be 33 percent the analgesic potency of morphine with a substantially longer duration of action.[3]

So far, little is currently known about this compound. It is a Schedule I controlled substance in the United States with an ACSCN of 9304 and a 2013 annual manufacturing quota of 2 grams.[4]

References

[edit]
  1. ^Anvisa (2023-03-31)."RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-04-04).Archived from the original on 2023-08-03. Retrieved2023-08-16.
  2. ^U.S. patent 2,104,058
  3. ^abReynolds AK, Randall LO (1957).Morphine & Allied Drugs. Toronto: University of Toronto Press. p. 194.
  4. ^"Quotas - 2013".Drug Enforcement Administration. United States Department of Justice.


μ-opioid
(MOR)
Agonists
(abridged;
full list)
Antagonists
δ-opioid
(DOR)
Agonists
Antagonists
κ-opioid
(KOR)
Agonists
Antagonists
Nociceptin
(NOP)
Agonists
Antagonists
Others


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