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| Names | |
|---|---|
| Preferred IUPAC name Methyl [(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraen-1-yl]phosphonofluoridate | |
| Other names MAFP | |
| Identifiers | |
3D model (JSmol) | |
| ChEMBL | |
| ChemSpider |
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| EC Number |
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| Properties | |
| C21H36FO2P | |
| Molar mass | 370.5 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Methoxy arachidonyl fluorophosphonate, commonly referred asMAFP, is an irreversible active site-directedenzyme inhibitor that inhibits nearly allserine hydrolases andserine proteases.[1] It inhibitsphospholipase A2 andfatty acid amide hydrolase with special potency, displayingIC50 values in the low-nanomolar range. In addition, it binds to theCB1 receptor in rat brain membrane preparations (IC50 = 20 nM),[2] but does not appear toagonize orantagonize the receptor,[3] though some related derivatives do show cannabinoid-like properties.[4]
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