| Total population | |
|---|---|
| 630 enrolled members[1] | |
| Regions with significant populations | |
| United States (California) | |
| Languages | |
| Ipai,[2][3]English | |
| Religion | |
| Traditional tribal religion, Christianity (Roman Catholicism) | |
| Related ethnic groups | |
| otherPaipai, and Taipai |
TheMesa Grande Band of Diegueño Mission Indians of the Mesa Grande Reservation is afederally recognized tribe ofIipay Indians,[4] who are sometimes known asMission Indians.

TheMesa Grande Reservation (33°05′19″N116°45′07″W / 33.08861°N 116.75194°W /33.08861; -116.75194) is a federalIndian reservation located in easternSan Diego County, California, nearSanta Ysabel. Founded in 1875,[4] the reservation is 1,803 acres (7.30 km2) large. Approximately 180 of the 630 members of the tribe live on the reservation.[1] In 1973, 24 out of 261 enrolled tribal members lived on the reservation.[2]
The reservation was featured in the 1936 filmRamona.[5]
The Mesa Grande Band is headquartered in Mesa Grande, CA. They are governed by a democratically elected tribal council. Michael Linton is their current tribal chairperson.[6]
| Race / Ethnicity(NH = Non-Hispanic) | Pop 2000[7] | Pop 2010[8] | Pop 2020[9] | % 2000 | % 2010 | % 2020 |
|---|---|---|---|---|---|---|
| White alone (NH) | 6 | 6 | 7 | 8.00% | 6.12% | 8.05% |
| Black or African American alone (NH) | 0 | 0 | 0 | 0.00% | 0.00% | 0.00% |
| Native American orAlaska Native alone (NH) | 42 | 90 | 55 | 56.00% | 91.84% | 63.22% |
| Asian alone (NH) | 0 | 0 | 0 | 0.00% | 0.00% | 0.00% |
| Native Hawaiian orPacific Islander alone (NH) | 0 | 0 | 0 | 0.00% | 0.00% | 0.00% |
| Other race alone (NH) | 0 | 0 | 0 | 0.00% | 0.00% | 0.00% |
| Mixed race or Multiracial (NH) | 4 | 1 | 4 | 5.33% | 1.02% | 4.60% |
| Hispanic or Latino (any race) | 23 | 1 | 21 | 30.67% | 1.02% | 24.14% |
| Total | 75 | 98 | 87 | 100.00% | 100.00% | 100.00% |