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| Clinical data | |
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| Other names | 4-Hydroxyanisole;para-Guaiacol |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a682437 |
| Routes of administration | Topical |
| ATC code | |
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| Identifiers | |
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| ChEMBL | |
| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.005.246 |
| Chemical and physical data | |
| Formula | C7H8O2 |
| Molar mass | 124.139 g·mol−1 |
| Density | 1.55 g/cm3 |
| Melting point | 52.5 °C (126.5 °F) |
| Boiling point | 243 °C (469 °F) |
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Mequinol,MeHQ or4-methoxyphenol, is anorganic compound with the formulaCH3OC6H4OH. It is aphenol with amethoxy group in the para position. A colorless solid, it is used indermatology[1] andorganic chemistry.[2]
Mequinol is a commonactive ingredient intopical drugs used forskin depigmentation. As a topical drug mequinol is often mixed withtretinoin, a topicalretinoid. A commonformulation for this drug is anethanolic solution of 2% mequinol and 0.01% tretinoin by mass.[1]Dermatologists commonly prescribe the drug to treatliver spots.
Lower dosages of mequinol have been used in conjunction with aQ-switchedlaser to depigment skin in patients withdisseminatedidiopathicvitiligo.[3]
In organic chemistry 4-methoxyphenol is used as apolymerisation inhibitor (e.g.acrylates orstyrene monomers).[2]
4-Methoxyphenol can be produced fromp-benzoquinone andmethanol via afree radical reaction.[4][5]
The U.S.National Institute for Occupational Safety and Health (NIOSH) has set arecommended exposure limit (REL) of 5 mg/m3 over an 8-hour workday.[6]
