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Membrane dipeptidase (EC 3.4.13.19,renal dipeptidase,dehydropeptidase I (DPH I),dipeptidase,aminodipeptidase,dipeptide hydrolase,dipeptidyl hydrolase,nonspecific dipeptidase,glycosyl-phosphatidylinositol-anchored renal dipeptidase,MBD,MDP,leukotriene D₄ hydrolase) is anenzyme.^[1]^[2]^[3]^[4] This enzymecatalyses the followingchemical reaction

Hydrolysis ofdipeptides (e.g.,leukotriene D₄,cystinyl-bis-glycine, someβ-lactam antibiotics (e.g.,carbapenem))

This membrane-bound, zinc enzyme has broad specificity.

Inhibitors includebestatin andcilastatin.

Genes

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Dipeptidase 1 (DPEP1)
Dipeptidase 2 (DPEP2)
Dipeptidase 3 (DPEP3)

References

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^Campbell BJ, Lin YC, Davis RV, Ballew E (May 1966). "The purification and properties of a particulate renal dipeptidase".Biochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation.118 (2):371–86.doi:10.1016/s0926-6593(66)80046-2.PMID 5961612.
^Campbell, B.J. (1970). "Renal dipeptidase".Proteolytic Enzymes. Methods Enzymol. Vol. 19. pp. 722–729.doi:10.1016/0076-6879(70)19059-8.ISBN 978-0-12-181881-4.
^Kropp H, Sundelof JG, Hajdu R, Kahan FM (July 1982)."Metabolism of thienamycin and related carbapenem antibiotics by the renal dipeptidase, dehydropeptidase".Antimicrobial Agents and Chemotherapy.22 (1):62–70.doi:10.1128/aac.22.1.62.PMC 183675.PMID 7125632.
^Hooper NM, Keen JN, Turner AJ (January 1990)."Characterization of the glycosyl-phosphatidylinositol-anchored human renal dipeptidase reveals that it is more extensively glycosylated than the pig enzyme".The Biochemical Journal.265 (2):429–33.doi:10.1042/bj2650429.PMC 1136904.PMID 2137335.

External links

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Membrane+dipeptidase at the U.S. National Library of MedicineMedical Subject Headings (MeSH)

v t e Metabolism:lipid metabolism –eicosanoid metabolismenzymes
Precursor	Phospholipase A2 Phospholipase C Diacylglycerol lipase
Prostanoids	Cyclooxygenase PTGS1 PTGS2 PGD2 synthase PGE synthase Prostaglandin-E2 9-reductase PGI2 synthase TXA synthase
Leukotrienes	5-Lipoxygenase activating protein/Arachidonate 5-lipoxygenase LTA4 hydrolase (B4 synthesis) LTC4 synthase Gamma-glutamyl transpeptidase LTD4 hydrolase
Ungrouped	HPGD

Leukotriene signaling modulators

Receptor
(ligands)

BLTTooltip Leukotriene B4 receptor

BLT₁Tooltip Leukotriene B4 receptor 1	Agonists:12-HETE 20-Hydroxy-LTB₄ Leukotriene B₄ LY-255283 Antagonists:20-Carboxy-LTB₄ Amelubant CGS-23131 (LY-223982) CGS-25019C CP-105696 CP-195543 Etalocib LY-293111 Moxilubant ONO-4057 RG-14893 RP-69698 SB-209247 SC-53228 Ticolubant U-75302 ZK-158252
BLT₂Tooltip Leukotriene B4 receptor 2	Agonists:12-HETE 12-HHT 12-HpETE 15-HETE 15-HpETE 20-Hydroxy-LTB₄ Leukotriene B₄ Antagonists:CP-195543 LY-255283 ZK-158252

CysLTTooltip Cysteinyl leukotriene receptor

CysLT₁Tooltip Cysteinyl leukotriene receptor 1	Agonists:Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists:Ablukast BAYu9773 BAYu9916 BAYx7195 Cinalukast FPL-55712 ICI-198615 Iralukast LY-170680 Masilukast MK-571 Montelukast ONO-1078 Pobilukast Pranlukast Ritolukast SKF-104353 SR-2640 Sulukast Tipelukast Tomelukast Verlukast Zafirlukast ZD-3523 Gemilukast Quinotolast
CysLT₂Tooltip Cysteinyl leukotriene receptor 2	Agonists:Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists:BAYu9773 BAYu9916
CysLT_ETooltip Cysteinyl leukotriene receptor E	Agonists:Leukotriene E₄

Enzyme
(inhibitors)

5-LOXTooltip Arachidonate 5-lipoxygenase	2-TEDC Baicalein BW-A4C BW-B70C Caffeic acid CDC CJ-13610 Curcumin Fenleuton Hyperforin Hypericum perforatum (St. John's Wort) Meclofenamic acid (meclofenamate) Minocycline N-Stearoyldopamine Timegadine Zileuton FLAPTooltip Arachidonate 5-lipoxygenase-activating protein inhibitors:AM-103 AM-679 BAYx1005 MK-591 MK-886
12-LOXTooltip Arachidonate 12-lipoxygenase	2-TEDC 3-Methoxytropolone Baicalein CDC
15-LOXTooltip Arachidonate 15-lipoxygenase	2-TEDC CDC KNX-100 (SOC-1) Luteolin PD-146176
LTA₄HTooltip Leukotriene A4 hydrolase	Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin)
LTB₄HTooltip Leukotriene B4 ω-hydroxylase	17-Octadecynoic acid
LTC₄STooltip Leukotriene C4 synthase	Azelastine MK-886
LTC₄HTooltip Leukotriene C4 hydrolase	Acivicin Serine-borate complex
LTD₄Tooltip Leukotriene D4 hydrolase	Cilastatin Ubenimex (bestatin)

Others

See also: Receptor/signaling modulators; Prostanoid signaling modulators

Hydrolase:proteases (EC 3.4)

3.4.11-19:Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases:Cathepsin A DD-Transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25:Endopeptidase

Other/ungrouped:Amyloid precursor protein secretase

3.4.99: Unknown

Staphylokinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases (list) EC2Transferases (list) EC3Hydrolases (list) EC4Lyases (list) EC5Isomerases (list) EC6Ligases (list) EC7Translocases (list)

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Category:

EC 3.4.13

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