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| Clinical data | |
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| Other names | MP; Methylhydroxyprogesterone; 6α-Methyl-17α-hydroxyprogesterone; 6α-Methyl-17α-hydroxypregn-4-en-3,20-dione |
| Drug class | Progestin;Progestogen |
| ATC code |
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| Identifiers | |
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| CAS Number | |
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| CompTox Dashboard(EPA) | |
| ECHA InfoCard | 100.007.545 |
| Chemical and physical data | |
| Formula | C22H32O3 |
| Molar mass | 344.495 g·mol−1 |
| 3D model (JSmol) | |
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Medroxyprogesterone (MP), is aprogestin which is not used medically.[1][2][3][4] A derivative,medroxyprogesterone acetate (MPA), is used as a medication in humans, and is far more widely known in comparison.[5]Medroxyprogesterone is sometimes used as a synonym formedroxyprogesterone acetate,[5] and what is almost always being referred to when the term is used is MPA and not medroxyprogesterone.[6]
Compared to MPA, medroxyprogesterone is over two orders of magnitude less potent as aprogestogen.[7] Medroxyprogesterone is also notable in that it is a minormetabolite of MPA.[8] In addition to its progestagenic activity, medroxyprogesterone is a weakantiandrogenin vitro on humanandrogen receptor.[9]
| Compound | Ki | EC50Tooltip Half-maximal effective concentrationa | EC50b |
|---|---|---|---|
| Progesterone | 4.3 | 0.9 | 25 |
| Medroxyprogesterone | 241 | 47 | 32 |
| Medroxyprogesterone acetate | 1.2 | 0.6 | 0.15 |
| Values are nM.a = Coactivator recruitment.b = Reporter cell line. | |||
Medroxyprogesterone, also known as 6α-methyl-17α-hydroxyprogesterone or as 6α-methyl-17α-hydroxypregn-4-en-3,20-dione, is asyntheticpregnanesteroid and aderivative ofprogesterone.[1][2] It is specifically a derivative of17α-hydroxyprogesterone with amethyl group at the C6α position.[1][2] The generic name of medroxyprogesterone is a contraction of 6α-methyl-17α-hydroxyprogesterone. It is closely related tomedrogestone as well as other unesterified 17α-hydroxyprogesterone derivatives such aschlormadinone,cyproterone, andmegestrol.[1][2]
Medroxyprogesterone is thegeneric name of the drug and itsINNTooltip International Nonproprietary Name andBANTooltip British Approved Name.[1][2][4]
Brand Name
Meprate 10 Tablets (practo)