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| ECHA InfoCard | 100.054.618 |
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| Formula | C20H24N2O5 |
| Molar mass | 372.421 g·mol−1 |
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Medroxalol is avasodilatorbeta blocker also classified as a mixed receptor blocker as it blocks both alpha and beta receptors.[1]
For the first step,salicylamide (1) is the subject of aFriedel-Crafts acetylation and then the aromaticmethyl ketone ishalogenated. in the usual manner. The bromide in2 is then displaced by the nitrogen inN-benzyl-1-(3',4'-methylenedioxyphenyl)-3-butylamine (3), which is itself prepared byreductive amination on the corresponding ketone. The product of the last step (4) iscatalytically hydrogenated. This serves the dual purpose both of reducing the ketone and removing the benzyl protecting group affording the product medroxalol (5). Note that a benzyl protecting group is not necessarily used.
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