Systems theory in medical sciences: The scope of systems theory in the medical sciences is searching for and modelling of physiological dynamics in the intact and diseased organism.[3][4][5] Its aim is to arrive at deeper insights into the organizational principles of life and its perturbations.[2][6][7] Based on cybernetic models, improved diagnostical strategies[8][9][10] and methods for personalised therapy of chronic diseases have been developed.[11][12][8][13][14][15] With focus on medical application this field is also referred to assystems medicine.[16]
Medical information andcommunication theory: Motivated by the awareness of information being an essential principle of life, the application of communication theory to biomedicine aims at a mathematical description of signalling processes and information storage in different physiological layers.[2] This attempt also includes theories on the information theory of the genetic code.[17][18][19][20][21]
Connectionism: Connectionistic models describe information processing in neural networks – thus forming a bridge between biological and technological research.[2]
Medical decision theory (MDT): The Goal of MDT is to gather evidence based foundations for decision making in the clinical setting.[2]
^Fricke, O; Lehmkuhl, G; Schoenau, E (April 2006). "The principle of regulation in biology--from bone to eating behavior".Experimental and Clinical Endocrinology & Diabetes.114 (4):197–203.doi:10.1055/s-2006-924068.PMID16705553.
^Fricke, O; Lehmkuhl, G; Pfaff, DW (February 2006). "Cybernetic principles in the systematic concept of hypothalamic feeding control".European Journal of Endocrinology.154 (2):167–73.doi:10.1530/eje.1.02081.PMID16452529.
^Midgley, JE; Hoermann, R; Larisch, R; Dietrich, JW (April 2013). "Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model".Journal of Clinical Pathology.66 (4):335–42.doi:10.1136/jclinpath-2012-201213.PMID23423518.
^Goede, SL; Leow, MK; Smit, JW; Dietrich, JW (March 2014). "A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications".Mathematical Biosciences.249:1–7.doi:10.1016/j.mbs.2014.01.001.PMID24480737.
^Goede, SL; Leow, MK; Smit, JW; Klein, HH; Dietrich, JW (June 2014). "Hypothalamus-pituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges".Bulletin of Mathematical Biology.76 (6):1270–87.doi:10.1007/s11538-014-9955-5.PMID24789568.
^Li, E; Yen, PM; Dietrich, JW; Leow, MK (May 2021). "Profiling retrospective thyroid function data in complete thyroidectomy patients to investigate the HPT axis set point (PREDICT-IT)".Journal of Endocrinological Investigation.44 (5):969–977.doi:10.1007/s40618-020-01390-7.PMID32808162.
^Alon, Uri (2024).Systems medicine: physiological circuits and the dynamics of disease (First ed.). Boca Rato London New York: CRC Press, Taylor & Francis Group.ISBN978-1-032-41185-9.
^Battail, Gérard (2007). "Information Theory and Error-Correcting Codes In Genetics and Biological Evolution".Introduction to Biosemiotics:299–345.doi:10.1007/1-4020-4814-9_13.ISBN978-1-4020-4813-5.
^Ramakrishnan, Nithya; Bose, R. (20 August 2012). "Dipole entropy based techniques for segmentation of introns and exons in DNA".Applied Physics Letters.101 (8): 083701.Bibcode:2012ApPhL.101h3701R.doi:10.1063/1.4747205.
V.V. Parin (1959), "Introduction to medical Cybernetics" inNASA Technical Translation no.F-459-F-462, National Aeronautics and Space Administration, 1959.
C.A. Muses (1965). "Aspects of some crucial problems in biological and medical cybernetics". In:Progress in biocybernetics, 1965.