| Medial septal nucleus | |
|---|---|
 Medial septal nucleus of the mouse brain | |
| Details | |
| Identifiers | |
| Latin | nucleus septalis medialis |
| NeuroNames | 262 |
| NeuroLex ID | birnlex_1668 |
| TA98 | A14.1.09.269 A14.1.09.446 |
| FMA | 61879 |
| Anatomical terms of neuroanatomy | |
Themedial septal nucleus (MS) is one of theseptal nuclei. Neurons in this nucleus give rise to the bulk of efferents from the septal nuclei. A major projection from the medial septal nucleus terminates in thehippocampal formation.[1]
It plays a role in the generation oftheta waves in the hippocampus.[2] Specifically, theGABAergic cells of the medial septum that act as theta pacemakers targetdentate gyrus, CA3, and CA1 interneurons. Pacemaking MS interneurons expresshyperpolarization-activated cyclic nucleotide-gated (HCN) channels which likely, at least partially, mediate their pacemaker properties.[3]
It is composed of GABAergic cells, glutamatergic cells, and cholinergic cells. Each cell-type carries out different functions. In addition to the theta wave generation, it has recently been discovered that medial septum also serves as an important node for sensory valence processing. For example, Vglut2 neurons in medial septum respond strongly to noxious sensory stimulation.
 | Thisneuroanatomy article is astub. You can help Wikipedia byexpanding it. |
