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Mavacoxib

From Wikipedia, the free encyclopedia
Veterinary drug

Pharmaceutical compound
Mavacoxib
Clinical data
Trade namesTrocoxil
AHFS/Drugs.comInternational Drug Names
ATCvet code
Legal status
Legal status
Identifiers
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
CompTox Dashboard(EPA)
ECHA InfoCard100.248.948Edit this at Wikidata
Chemical and physical data
FormulaC16H11F4N3O2S
Molar mass385.34 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1C2=CC(=NN2C3=CC=C(C=C3)S(=O)(=O)N)C(F)(F)F)F
  • InChI=1S/C16H11F4N3O2S/c17-11-3-1-10(2-4-11)14-9-15(16(18,19)20)22-23(14)12-5-7-13(8-6-12)26(21,24)25/h1-9H,(H2,21,24,25)
  • Key:TTZNQDOUNXBMJV-UHFFFAOYSA-N

Mavacoxib (trade nameTrocoxil) is aveterinary drug used to treat pain and inflammation in dogs with degenerative jointdisease.[2] It acts as aCOX-2 inhibitor.[3]

Mavacoxib, along with several other COX-2 selective inhibitors, includingcelecoxib,valdecoxib, andparecoxib, were discovered by a team at theSearle division ofMonsanto led byJohn Talley.[4][5]

References

[edit]
  1. ^"Trocoxil EPAR".European Medicines Agency. 22 September 2008. Retrieved26 June 2024.
  2. ^European Public Assessment Report (EPAR): TrocoxilArchived 17 March 2018 at theWayback Machine,European Medicines Agency
  3. ^Cox SR, Lesman SP, Boucher JF, Krautmann MJ, Hummel BD, Savides M, et al. (October 2010). "The pharmacokinetics of mavacoxib, a long-acting COX-2 inhibitor, in young adult laboratory dogs".Journal of Veterinary Pharmacology and Therapeutics.33 (5):461–70.doi:10.1111/j.1365-2885.2010.01165.x.PMID 20840390.{{cite journal}}: CS1 maint: overridden setting (link)
  4. ^Langreth R (23 June 2003)."The Chemical Cobbler".Forbes.{{cite news}}: CS1 maint: overridden setting (link)
  5. ^"Dr. John Talley: 2001 St. Louis Awardee"(PDF).Chemical Bond.52 (5). St. Louis Section, American Chemical Society: 2. May 2001. Archived fromthe original(PDF) on 15 April 2018.
pyrazolones /
pyrazolidines
salicylates
acetic acid derivatives
and related substances
oxicams
propionic acid
derivatives (profens)
n-arylanthranilic
acids (fenamates)
COX-2 inhibitors
(coxibs)
other
NSAID
combinations
Key:underline indicates initially developed first-in-class compound of specific group;#WHO-Essential Medicines;withdrawn drugs;veterinary use.
Receptor
(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor
DP1Tooltip Prostaglandin D2 receptor 1
DP2Tooltip Prostaglandin D2 receptor 2
EP (E2)Tooltip Prostaglandin E2 receptor
EP1Tooltip Prostaglandin EP1 receptor
EP2Tooltip Prostaglandin EP2 receptor
EP3Tooltip Prostaglandin EP3 receptor
EP4Tooltip Prostaglandin EP4 receptor
Unsorted
FP (F)Tooltip Prostaglandin F receptor
IP (I2)Tooltip Prostacyclin receptor
TP (TXA2)Tooltip Thromboxane receptor
Unsorted
Enzyme
(inhibitors)
COX
(
PTGS)
PGD2STooltip Prostaglandin D synthase
PGESTooltip Prostaglandin E synthase
PGFSTooltip Prostaglandin F synthase
PGI2STooltip Prostacyclin synthase
TXASTooltip Thromboxane A synthase
Others
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