 | |
| Names | |
|---|---|
| IUPAC name 2α,3β-Dihydroxyolean-12-en-28-oic acid | |
| Systematic IUPAC name (4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-Dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-octadecahydropicene-4a(2H)-carboxylic acid | |
| Other names Crategolic acid; Masilinic acid; Crataegolic acid | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
|
| ECHA InfoCard | 100.128.873 |
| KEGG |
|
| UNII | |
| |
| |
| Properties | |
| C30H48O4 | |
| Molar mass | 472.710 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct ofolive oil extraction. It is a member of the group oftriterpenes known asoleananes.
In vitro study shows that maslinic acidinhibitsserine proteases, key enzymes necessary for the spread ofHIV within an individual's body.[1] It also hasin vitroantiproliferative effects on colon cancer cells.[2] Maslinic acid increasesEAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats.[3] Additionally, maslinic acid serves as a glycogen phosphorylase inhibitor in mouse liver,[4][5] as evidenced by increased glycogen accumulation in rainbow trout liver.[6]
Maslinic acid demonstrates antioxidant capabilities against oxygen and nitrogen reactive species.[7][8] It also exhibits a suppressive impact on proinflammatory cytokines like TNF-α and IL-6 in murine macrophages.[8] These mechanisms could contribute to enhanced protein synthesis, growth rates, and joint support.[9] Maslinic acid has been shown to improve muscle mass in the elderly when combined withresistance exercise.[10]
