| Marneral synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.53 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| |||||||||
Marneral synthase (EC5.4.99.53) is anenzyme withsystematic name(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming).[1] This enzymecatalyses the followingchemical reaction
Marneral is atriterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization. This aldehyde gains its name from its structural similarity to a class triterpenes commonly found in members of theIridaceae, originally identified by Dr. Franz-Josef Marner[1]
This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s.[2]
