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Mark Achtman

From Wikipedia, the free encyclopedia
Canadian bacteriologist

Mark Achtman
Mark Achtman in 2015, portrait via theRoyal Society
Alma mater
ChildrenAriel Achtman, Jane Achtman
Awards
Scientific career
Fields
Institutions
ThesisA Genetic Study of the F-Factor (1969)
Doctoral advisorAlvin J. Clark
Other academic advisorsThomas Trautner
Websitewww2.warwick.ac.uk/fac/med/staff/machtman

Mark AchtmanFRS[1] is an emeritus Professor of Bacterial Population Genetics atWarwick Medical School, part of theUniversity of Warwick in the UK.[2][3][4][5]

Education

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Achtman was educated at McGill University and graduated in 1963 (B. Sc. Hon. Bacteriology & Immunology). He then attended theUniversity of Manitoba where he was awarded a Master of Science degree in 1965 for research onhemagglutination inadenovirus.[6] He went on to complete a PhD onbacterial fertility factor at theUniversity of California, Berkeley in 1969.[7][8]

Research

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Achtman's research interests are in thepopulation genetics ofpathogenic bacteria such asVibrio cholerae,[9]Salmonella,[10][11]Yersinia pestis,[12][13]Neisseria meningitidis,[14]Escherichia coli,[8]Helicobacter pylori,[15] andBordetella.[16] Achtman was one of the inventors ofmultilocus sequence typing.[17] His research has been funded by theBiotechnology and Biological Sciences Research Council (BBSRC) andMedical Research Council (MRC).[18]

Awards and honours

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Achtman was elected aFellow of the Royal Society (FRS) in 2015. His nomination reads:[1]

Mark Achtman co-pioneered the development ofbacterial population genetics and carried out influential studies characterising strains associated with epidemics ofmeningococcal disease in Africa. He has undertaken remarkable and highly innovative studies on the humangut pathogen, Helicobacter pylori, showing its ancient association with humans and the ability of genetic studies of thispathogen to complement linguistic andhuman genetic studies to trace the ancient migrations of its human host. He has also carried out elegant and incisive genetic studies of Yersinia pestis to explore the origins and spread of plaguepandemics.

References

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  1. ^abc"Professor Mark Achtman FRS". London: The Royal Society. Archived fromthe original on 2 May 2015.
  2. ^abcMark Achtman publications indexed byGoogle Scholar
  3. ^Mark Achtman's publications indexed by theScopus bibliographic database.(subscription required)
  4. ^Kay, G. L.; Sergeant, M. J.; Zhou, Z; Chan, J. Z.; Millard, A; Quick, J; Szikossy, I; Pap, I; Spigelman, M; Loman, N. J.; Achtman, M; Donoghue, H. D.; Pallen, M. J. (2015)."Eighteenth-century genomes show that mixed infections were common at time of peak tuberculosis in Europe".Nature Communications.6: 6717.Bibcode:2015NatCo...6.6717K.doi:10.1038/ncomms7717.PMC 4396363.PMID 25848958.
  5. ^Achtman, M; Zhou, Z (2014)."Distinct genealogies for plasmids and chromosome".PLOS Genetics.10 (12) e1004874.doi:10.1371/journal.pgen.1004874.PMC 4270482.PMID 25521852.Open access icon
  6. ^Achtman, Mark (1965).Adenovirus 7: a study of the haemagglutinin and the haemagglutinating system (PhD thesis). University of Manitoba.OCLC 184853811.
  7. ^Achtman, Mark (1969).A Genetic Study of the F-Factor (PhD thesis). University of California, Berkeley.OCLC 29422094.ProQuest 302395896.
  8. ^abAchtman, M; Willetts, N; Clark, A. J. (1971)."Beginning a genetic analysis of conjugational transfer determined by the F factor in Escherichia coli by isolation and characterization of transfer-deficient mutants".Journal of Bacteriology.106 (2):529–38.doi:10.1128/JB.106.2.529-538.1971.PMC 285127.PMID 4929865.
  9. ^Didelot, X; Pang, B; Zhou, Z; McCann, A; Ni, P; Li, D;Achtman, M; Kan, B (2015)."The role of china in the global spread of the current cholera pandemic".PLOS Genetics.11 (3) e1005072.doi:10.1371/journal.pgen.1005072.PMC 4358972.PMID 25768799.Open access icon
  10. ^Zhou, Z; McCann, A; Weill, F. X.; Blin, C; Nair, S; Wain, J;Dougan, G;Achtman, M (2014)."Transient Darwinian selection in Salmonella enterica serovar Paratyphi a during 450 years of global spread of enteric fever".Proceedings of the National Academy of Sciences of the United States of America.111 (33):12199–204.Bibcode:2014PNAS..11112199Z.doi:10.1073/pnas.1411012111.PMC 4143038.PMID 25092320.Open access icon
  11. ^Achtman, M.; Wain, J.; Weill, F. O. X.; Nair, S.; Zhou, Z.; Sangal, V.; Krauland, M. G.; Hale, J. L.; Harbottle, H.; Uesbeck, A.;Dougan, G.; Harrison, L. H.; Brisse, S.; S. Enterica MLST Study Group (2012). Bessen, Debra E (ed.)."Multilocus Sequence Typing as a Replacement for Serotyping in Salmonella enterica".PLOS Pathogens.8 (6) e1002776.doi:10.1371/journal.ppat.1002776.PMC 3380943.PMID 22737074.Open access icon
  12. ^Reuter, S; Connor, T. R.; Barquist, L; Walker, D; Feltwell, T; Harris, S. R.; Fookes, M; Hall, M. E.; Petty, N. K.; Fuchs, T. M.; Corander, J; Dufour, M; Ringwood, T; Savin, C; Bouchier, C; Martin, L; Miettinen, M; Shubin, M; Riehm, J. M.; Laukkanen-Ninios, R; Sihvonen, L. M.; Siitonen, A; Skurnik, M; Falcão, J. P.; Fukushima, H; Scholz, H. C.; Prentice, M. B.; Wren, B. W.; Parkhill, J; et al. (2014)."Parallel independent evolution of pathogenicity within the genus Yersinia".Proceedings of the National Academy of Sciences.111 (18):6768–73.Bibcode:2014PNAS..111.6768R.doi:10.1073/pnas.1317161111.PMC 4020045.PMID 24753568.
  13. ^Mark Achtman on the Plague onYouTube
  14. ^Parkhill, J.;Achtman, M.; James, K. D.; Bentley, S. D.; Churcher, C.; Klee, S. R.; Morelli, G.; Basham, D.; Brown, D.; Chillingworth, T.; Davies, R. M.; Davis, P.; Devlin, K.; Feltwell, T.; Hamlin, N.; Holroyd, S.; Jagels, K.; Leather, S.; Moule, S.; Mungall, K.; Quail, M. A.; Rajandream, M. -A.; Rutherford, K. M.; Simmonds, M.; Skelton, J.; Whitehead, S.; Spratt, B. G.; Barrell, B. G. (2000). "Complete DNA sequence of a serogroup a strain of Neisseria meningitidis Z2491".Nature.404 (6777):502–6.Bibcode:2000Natur.404..502P.doi:10.1038/35006655.PMID 10761919.S2CID 4430718.
  15. ^Falush, D; Wirth, T; Linz, B; Pritchard, J. K.; Stephens, M; Kidd, M; Blaser, M. J.; Graham, D. Y.; Vacher, S; Perez-Perez, G. I.; Yamaoka, Y; Mégraud, F; Otto, K; Reichard, U; Katzowitsch, E; Wang, X; Achtman, M; Suerbaum, S (2003). "Traces of human migrations in Helicobacter pylori populations".Science.299 (5612):1582–5.Bibcode:2003Sci...299.1582F.doi:10.1126/science.1080857.PMID 12624269.S2CID 1515436.
  16. ^Parkhill, J.; Sebaihia, M.; Preston, A.; Murphy, L. D.; Thomson, N.; Harris, D. E.; Holden, M. T. G.; Churcher, C. M.; Bentley, S. D.; Mungall, K. L.; Cerdeño-Tárraga, A. M.; Temple, L.; James, K.; Harris, B.; Quail, M. A.;Achtman, M.; Atkin, R.; Baker, S.; Basham, D.; Bason, N.; Cherevach, I.; Chillingworth, T.; Collins, M.; Cronin, A.; Davis, P.; Doggett, J.; Feltwell, T.; Goble, A.; Hamlin, N.; et al. (2003)."Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica".Nature Genetics.35 (1):32–40.doi:10.1038/ng1227.PMID 12910271.
  17. ^Maiden, M. C.; Bygraves, J. A.; Feil, E; Morelli, G; Russell, J. E.; Urwin, R; Zhang, Q; Zhou, J; Zurth, K; Caugant, D. A.; Feavers, I. M.; Achtman, M; Spratt, B. G. (1998)."Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms".Proceedings of the National Academy of Sciences of the United States of America.95 (6):3140–5.Bibcode:1998PNAS...95.3140M.doi:10.1073/pnas.95.6.3140.PMC 19708.PMID 9501229.
  18. ^"UK Government Research Grants awarded to Mark Achtman".Research Councils UK. Archived fromthe original on 13 May 2015.
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