| Maria Manuela | |
|---|---|
| Princess of Portugal,Princess of Asturias | |
Portrait byAntonis Mor | |
| Duchess consort of Milan | |
| Tenure | 12 November 1543 – 12 July 1545 |
| Born | 15 October 1527 Coimbra |
| Died | 12 July 1545(1545-07-12) (aged 17) Valladolid |
| Burial | |
| Spouse | |
| Issue | Carlos, Prince of Asturias |
| House | Aviz |
| Father | John III of Portugal |
| Mother | Catherine of Austria |
DonaMaria Manuela (15 October 1527 – 12 July 1545[1]) was the eldest daughter and second child of KingJohn III of Portugal and his wifeCatherine of Austria.[2] She wasPrincess of Asturias andDuchess of Milan as the first wife of the futurePhilip II of Spain, andPrincess of Portugal as heir presumptive to the Portuguese throne between 1527 and 1535.
Maria was born inCoimbra on 15 October 1527 and was one of the two children of John III to survive childhood.[2] In her youth, Maria received a humanistic education that was considered typical for a princess of her time.[3]
She married her double first cousinPhilip II of Spain on 12 November 1543 atSalamanca.[4] As she was to be married to the Prince of Asturias,heir apparent to the Spanish crown, and being anInfanta of Portugal, their wedding became one of the most remarkable in the history of Spain due to its opulence. Contemporary writers have left detailed descriptions of the journey fromMadrid toBadajoz to Salamanca to receive the princess and of the luxuries she was given by theDuke of Medina Sidonia in Badajoz.
She gave birth to their sonCarlos on 8 July 1545 inValladolid, but died four days later due to ahaemorrhage.[1] She was initially buried in theRoyal Chapel of Granada on 30 March 1549 but was later transferred toRoyal Crypt of the Monastery of El Escorial.

| Ancestors of Maria Manuela of Portugal |
|---|
{{cite book}}:ISBN / Date incompatibility (help)Maria Manuela, Princess of Portugal Cadet branch of theHouse of Burgundy Born: 15 October 1527 Died: 12 August 1545 | ||
| Portuguese royalty | ||
|---|---|---|
| Preceded by | Princess of Portugal 1527–1535 | Succeeded by |