Harden was born in theLa Jolla area of San Diego, California, the daughter ofTexas natives Beverly Harden (née Bushfield), ahousewife, and Thad Harold Harden (1932–2002), who was a Captain and fighter pilot who served 30 years in theUnited States Navy.[2] She has three sisters and one brother.[3]
Harden's brother is named Thaddeus, as are her father and her former husband. Harden's family frequently moved because of her father's job, living in Japan, Germany,Greece, California, andMaryland.[4]
Harden's first film role was in a 1979 student-produced film at the University of Texas. Throughout the 1980s, she appeared in several television programs, includingSimon & Simon,Kojak, andCBS Summer Playhouse. She appeared inThe Imagemaker (1986), her first film screen role, in which she played a stage manager. She appeared in the Coen brothers'Miller's Crossing (1990), a 1930s mobster drama in which she first gained wide exposure. Even so, at the time, living in New York City, she had to go back to doing catering jobs "because I didn't have any money".[6]
In 2000, Harden won theAcademy Award forBest Supporting Actress for her portrayal of painterLee Krasner in the biographical filmPollock. In 2004, she received a second Academy Award nomination for Best Supporting Actress for her performance in the mystery crime dramaMystic River.
Harden guest-starred asFBI undercover agent Dana Lewis posing as awhite supremacist in "Raw", an episode of the popular crime dramaLaw & Order: Special Victims Unit. This role earned Harden her firstEmmy Award nomination for best guest actress in a drama series in 2007. She reprised the role in the series' eighth-season premiere and again in the 12th-season episode "Penetration" as a rape victim.
Harden appeared in several 2007 films, includingSean Penn'sInto the Wild and Frank Darabont'sThe Mist (oppositeThomas Jane andLaurie Holden), based on the novella byStephen King. Also in 2007, she shared top billing withKevin Bacon inRails & Ties, the directorial debut ofAlison Eastwood. Harden played a woman who has a mastectomy inHome (2008). (Her character inRails & Ties also had a mastectomy.) Scenes in both films required her to bare her breasts, with the missing breast removed usingcomputer-generated imagery. InHome, her co-stars include her daughter, Eulala Scheel. Harden starred in theChristmas Cottage, a story of the early artistic beginnings of the painterThomas Kinkade.
Harden appeared as a regular on theFX seriesDamages as a shrewd corporate attorney oppositeGlenn Close andWilliam Hurt in 2009. She received a2009 Emmy nomination for her role inThe Courageous Heart of Irena Sendler, a TV film also starringOscar-winnerAnna Paquin. She was a Best Supporting Actress in a TV Movie/Miniseries nominee and lost toShohreh Aghdashloo. If she had won this Emmy, Harden would have entered the elite group of "triple-crown" actors, those who have won the profession's three highest honors: the Academy Award (film), the Tony Award (stage), and the Emmy Award (television).
Harden returned to Broadway inYasmina Reza'sGod of Carnage, co-starring withJames Gandolfini,Hope Davis and Jeff Daniels, in 2009.[8] All three actors were nominated for a Tony Award; Harden won Best Actress in a Play.[9]
Harden reunited with her former Broadway co-starJeff Daniels as a new cast member onHBO's seriesThe Newsroom in 2013.[6] She played Christian Grey's mother, Grace Trevelyan Grey, in theFifty Shades film series from 2015 to 2018. Also in 2015, she began a starring role in the TV seriesCode Black. She stars in the 2022 CBS dramaSo Help Me Todd, since renewed for a second season.
In 1996, Harden married Thaddaeus Scheel, aprop master, with whom she worked onThe Spitfire Grill.[6] They have three children.[10][11][12] In February 2012, Harden filed for divorce from Scheel.[13]
Harden is an avidpotter, which she learned in high school, and then took up again while acting inAngels in America.[18][14] She is also a practitioner ofikebana, the art of Japanese flower arrangement, which her mother learned while they lived in Japan.[19] She gave a brief demonstration in 2007 onThe Martha Stewart Show and presented some works of her family, as well.[20]
In May 2018, a memoir calledThe Seasons of My Mother: A Memoir of Love, Family, and Flowers was published. The book details the story and bond of mother and daughter throughout time and how they are dealing with the largest struggle yet, her mother'sAlzheimer's disease. Harden created works ofikebana specifically for this book to illustrate the different seasons of her mother's life.[21][18]