 | |
| Names | |
|---|---|
| Preferred IUPAC name (5R)-5-Hydroxy-4-{(2R,6R)-6-hydroxy-5-[(3E)-4-methyl-6-(2,6,6-trimethylcyclohex-1-en-1-yl)hex-3-en-1-yl]-3,6-dihydro-2H-pyran-2-yl}furan-2(5H)-one | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
|
| KEGG |
|
| UNII | |
| |
| |
| Properties | |
| C25H36O5 | |
| Molar mass | 416.55034 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Manoalide is acalcium channel blocker. It has antibiotic, analgesic and anti-inflammatory effects and is found in somesponges, including the West Pacific speciesLuffariella variabilis.[1]Its functions are made possible by the permanent blockage ofphospholipase A2 and C[2] with lysine residues. This could be made possible through the functional groups incorporated in gamma-hydroxybutenolide, alpha-hydroxydihydropyran and the trimethylcyclohexenyl. The gamma-hydroxybutenolide ring is present in the reaction between manoalide and phospholipase A2, the hemiacetal in alpha-hydroxydihydropyran is needed for permanent binding and hydrophobic trimethylcyclohexenyl ring makes it possible for non-bonded interactions to interact between manoalide and phospholipase A2 to strengthen the reaction.[3] Due to its potential of permanent inhibition, it was made possible for it to take part in oral cancer[4] andhepatitis C[5] research.
{{cite book}}: CS1 maint: others (link)