Myosin light chain kinase, smooth muscle also known askinase-related protein (KRP) ortelokin is anenzyme that in humans is encoded by theMYLKgene.[5]
This gene, a muscle member of theimmunoglobulin superfamily, encodes amyosin light-chain kinase, which is a calcium-/calmodulin-dependent enzyme. This kinasephosphorylatesmyosin regulatory light chains to facilitate myosin interaction withactin filaments to produce contractile activity. This gene encodes bothsmooth muscle and nonmuscleisoforms. In addition, using a separatepromoter in anintron in the3' region, it encodestelokin, a small protein identical in sequence to theC-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. Apseudogene is located on the p arm of chromosome 3. Fourtranscript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.[6]
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
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