Interferon-induced GTP-binding protein Mx1 is aprotein that in humans is encoded by theMX1 gene.[5][6]
Inmice, theinterferon-inducible Mx protein is responsible for a specific antiviral state againstinfluenza virusinfection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin.[7] The protein encoded by thisgene is similar to the mouse protein as determined by itsantigenic relatedness, induction conditions, physicochemical properties, andamino acid analysis. Thiscytoplasmic protein is a member of both thedynamin superfamily and the family of largeGTPases.[6]
^Ciminski, Kevin; Chase, Geoffrey; Beer, Martin; Schwemmle, Martin (2021). "Influenza A Viruses: Understanding Human Host Determinants".Trends in Molecular Medicine.27 (2):104–112.doi:10.1016/j.molmed.2020.09.014.PMID33097424.S2CID225058479.
Weitz G, Bekisz J, Zoon K, Arnheiter H (1990). "Purification and characterization of a human Mx protein".J. Interferon Res.9 (6):679–89.doi:10.1089/jir.1989.9.679.PMID2607176.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon".Intervirology.43 (2):124–7.doi:10.1159/000025035.PMID10971132.S2CID19445539.
Engelhardt OG, Ullrich E, Kochs G, Haller O (2002). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies".Exp. Cell Res.271 (2):286–95.doi:10.1006/excr.2001.5380.PMID11716541.
Hijikata M, Mishiro S, Miyamoto C, et al. (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro".Intervirology.44 (6):379–82.doi:10.1159/000050075.PMID11805446.S2CID46752867.
