Interferon-induced GTP-binding protein Mx1 is aprotein that in humans is encoded by theMX1gene.[5][6]
Inmice, theinterferon-inducible Mx protein is responsible for a specific antiviral state againstinfluenza virusinfection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin.[7] The protein encoded by thisgene is similar to the mouse protein as determined by itsantigenic relatedness, induction conditions, physicochemical properties, andamino acid analysis. Thiscytoplasmic protein is a member of both thedynamin superfamily and the family of largeGTPases.[6]
Weitz G, Bekisz J, Zoon K, Arnheiter H (Dec 1989). "Purification and characterization of a human Mx protein".Journal of Interferon Research.9 (6):679–689.doi:10.1089/jir.1989.9.679.PMID2607176.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138 (1–2):171–174.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200 (1–2):149–156.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
Kochs G, Trost M, Janzen C, Haller O (Jul 1998). "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures".Methods.15 (3). San Diego, Calif.:255–263.doi:10.1006/meth.1998.0629.PMID9735310.
Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon".Intervirology.43 (2):124–127.doi:10.1159/000025035.PMID10971132.S2CID19445539.
Engelhardt OG, Ullrich E, Kochs G, Haller O (Dec 2001). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies".Experimental Cell Research.271 (2):286–295.doi:10.1006/excr.2001.5380.PMID11716541.
Hijikata M, Mishiro S, Miyamoto C, Furuichi Y, Hashimoto M, Ohta Y (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro".Intervirology.44 (6):379–382.doi:10.1159/000050075.PMID11805446.S2CID46752867.
