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MS4A3

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MS4A3
Identifiers
AliasesMS4A3, CD20L, HTM4, membrane spanning 4-domains A3
External IDsOMIM:606498;MGI:2158468;HomoloGene:4472;GeneCards:MS4A3;OMA:MS4A3 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for MS4A3
Genomic location for MS4A3
Band11q12.1Start60,056,587bp[1]
End60,071,115bp[1]
Gene location (Mouse)
Chromosome 19 (mouse)
Chr.Chromosome 19 (mouse)[2]
Chromosome 19 (mouse)
Genomic location for MS4A3
Genomic location for MS4A3
Band19|19 AStart11,606,860bp[2]
End11,618,215bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow

  • bone marrow cells

  • testicle

  • monocyte

  • blood

  • granulocyte

  • spleen

  • right lung

  • placenta

  • appendix
Top expressed in
  • tibiofemoral joint

  • granulocyte

  • fetal liver hematopoietic progenitor cell

  • bone marrow

  • lumbar spinal ganglion

  • gastrula

  • right ventricle

  • body of femur

  • embryo

  • olfactory epithelium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

932

170813

Ensembl

ENSG00000149516
ENSG00000284903

ENSMUSG00000024681

UniProt

Q96HJ5

Q920C4

RefSeq (mRNA)

NM_001031666
NM_001031809
NM_006138

NM_133246

RefSeq (protein)

NP_001026836
NP_001026979
NP_006129

NP_573509

Location (UCSC)Chr 11: 60.06 – 60.07 MbChr 19: 11.61 – 11.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Membrane-spanning 4-domains subfamily A member 3 is aprotein that in humans is encoded by theMS4A3gene.[5][6]

This gene encodes a member of themembrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described.[6]

Interactions

[edit]

MS4A3 has been shown tointeract withCDKN3.[7]

References

[edit]
  1. ^abcENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000024681Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994)."Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions".Proc Natl Acad Sci U S A.91 (21):10178–82.Bibcode:1994PNAS...9110178A.doi:10.1073/pnas.91.21.10178.PMC 44981.PMID 7524084.
  6. ^ab"Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
  7. ^Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002)."Human HTm4 is a hematopoietic cell cycle regulator".J. Clin. Invest.109 (1). United States:51–8.doi:10.1172/JCI14025.ISSN 0021-9738.PMC 150822.PMID 11781350.

Further reading

[edit]


Arrestin
Membrane-spanning 4A
Myelin
Pulmonary surfactant
Tetraspanin
Other/ungrouped


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