The allergic response involves the binding ofallergen to receptor-boundIgE followed by cell activation and the release of mediators responsible for the manifestations ofallergy. TheIgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface ofmast cells andbasophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of themembrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[6]
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