 | |
| Names | |
|---|---|
| IUPAC name (3R)-1-(4-Chlorophenyl)-3-[[4-(2-methoxyethyl)piperazin-1-yl]methyl]pyrrolidin-2-one | |
| Identifiers | |
| |
3D model (JSmol) | |
| ChemSpider | |
| |
| |
| Properties | |
| C18H26ClN3O2 | |
| Molar mass | 351.88 g·mol−1 |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
MS-377 is a selectiveantagonist of thesigma-1 receptor.[3] It possessesanti-psychotic properties.
MS-377 acts selectively at the sigma-1 receptor as an antagonist. It does not act ondopamine orserotonin receptors unlike mostanti-psychotics. Tests have shown that MS-377 could displace ligand binding from the sigma-1 receptor, but did this not happen at the sigma-2,5-HT2 andD2 receptors, suggesting that it is selective for the sigma-1 receptor.[4]
Despite not acting atserotonin anddopamine receptors, it still affects thosemonoamine systems. It has been shown that MS-377 reduced the release ofserotonin and dopamine induced byPCP.[5] It has also been shown to decreasemethamphetamine behavioral sensitization,[6] this is also observed with othersigma antagonists.[7]