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Mitochondrial ribosomal protein S6

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(Redirected fromMRPS6)

Protein-coding gene in the species Homo sapiens

MRPS6

Available structures

PDB

Ortholog search:PDBe RCSB

List of PDB id codes
3J9M

Identifiers

Aliases

MRPS6, C21orf101, MRP-S6, RPMS6, S6mt, mitochondrial ribosomal protein S6

External IDs

OMIM:611973;MGI:2153111;HomoloGene:41871;GeneCards:MRPS6;OMA:MRPS6 - orthologs

Gene location (Human)

Chr.	Chromosome 21 (human)^[1]

Band	21q22.11	Start	34,073,224bp^[1]
Band	21q22.11	End	34,143,034bp^[1]

Gene location (Mouse)

Chr.	Chromosome 16 (mouse)^[2]

Band	16\|16 C4	Start	91,855,158bp^[2]
Band	16\|16 C4	End	91,909,115bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

renal medulla

left lobe of thyroid gland

decidua

gonad

human kidney

right lobe of thyroid gland

tibial arteries

right adrenal cortex

right coronary artery

tibial nerve

Top expressed in

vestibular membrane of cochlear duct

Epithelium of choroid plexus

vestibular sensory epithelium

retinal pigment epithelium

epithelium of lens

endothelial cell of lymphatic vessel

ciliary body

right kidney

medullary collecting duct

sciatic nerve

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	structural constituent of ribosome rRNA binding protein binding small ribosomal subunit rRNA binding
Cellular component	small ribosomal subunit mitochondrial inner membrane ribosome mitochondrial small ribosomal subunit mitochondrion
Biological process	mitochondrial translational elongation mitochondrial translational termination protein biosynthesis mitochondrial translation
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


64968


121022

Ensembl


ENSG00000243927


ENSMUSG00000039680

UniProt


P82932


P58064

RefSeq (mRNA)


NM_032476


NM_080456

RefSeq (protein)


NP_115865


NP_536704

Location (UCSC)

Chr 21: 34.07 – 34.14 Mb

Chr 16: 91.86 – 91.91 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

28S ribosomal protein S6, mitochondrial is aprotein that in humans is encoded by theMRPS6gene.^[5]

Mammalianmitochondrial ribosomal proteins are encoded bynuclear genes and help inprotein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75%protein torRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition bysequence homology. This gene encodes a 28S subunit protein that belongs to theribosomal protein S6P family.Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q.^[5]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000243927 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000039680 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: MRPS6 mitochondrial ribosomal protein S6".

External links

[edit]

Overview of all the structural information available in thePDB forUniProt:P82932 (28S ribosomal protein S6, mitochondrial) at thePDBe-KB.

Protein biosynthesis:translation (bacterial,archaeal,eukaryotic)

Proteins

eIF1	eIF1 B SUI1 family eIF1A Y
eIF2	α kinase β γ eIF2A eIF2B 1 2 3 4 5 eIF2D
eIF3	A B C D E F G H I J K L M
eIF4	A 1 2 3 E1 2 3 G 1 2 3 B H
eIF5	EIF5 EIF5A 2 5B
eIF6	EIF6

Elongation factor

Bacterial/Mitochondrial	EF-Tu EF-Ts EF-G EF-4 EF-P TSFM GFM1 GFM2
Archaeal/Eukaryotic	a/eEF-1 A1 2 3 B P1 P2 P3 D E G a/eEF-2

Release factor

Class 1
- eRF1
Class 2/RF3
- GSPT1
- GSPT2

Ribosomal Proteins

Cytoplasmic

60S subunit	RPL3 RPL4 RPL5 RPL6 RPL7 RPL7A RPL8 RPL9 RPL10 RPL10A RPL10-like RPL11 RPL12 RPL13 RPL13A RPL14 RPL15 RPL17 RPL18 RPL18A RPL19 RPL21 RPL22 RPL23 RPL23A RPL24 RPL26 RPL27 RPL27A RPL28 RPL29 RPL30 RPL31 RPL32 RPL34 RPL35 RPL35A RPL36 RPL36A RPL37 RPL37A RPL38 RPL39 RPL40 RPL41 RPLP0 RPLP1 RPLP2 RRP15-like RSL24D1
40S subunit	RPSA RPS2 RPS3 RPS3A RPS4 (RPS4X,RPS4Y1,RPS4Y2) RPS5 RPS6 RPS7 RPS8 RPS9 RPS10 RPS11 RPS12 RPS13 RPS14 RPS15 RPS15A RPS16 RPS17 RPS18 RPS19 RPS20 RPS21 RPS23 RPS24 RPS25 RPS26 RPS27 RPS27A RPS28 RPS29 RPS30 RACK1

Mitochondrial

39S subunit	MRPL1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42
28S subunit	MRPS1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35

Other concepts

Ribosomal RNA /ribosome subunits

Archaea
(70S)

Large (50S):

Small (30S):

Bacteria
(70S)

Large (50S):

Small (30S):

Eukaryotes

Cytoplasmic (80S)	Large (60S): 5S 5.8S 28S Small (40S): 18S
Mitochondrial (55S)	Large (28S): MT-RNR2, 16S MT-tRNA^Val Small (39S): MT-RNR1, 12S
Chloroplast (70S)	Large (50S): 5S 4.5S 23S Small (30S): 16S