Protein-coding gene in the species Homo sapiens
Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is aprotein that in humans is encoded by the MRPS2gene.[5]
Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S2 family. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012].
- Overview of all the structural information available in thePDB forUniProt:Q9Y399 (Human 28S ribosomal protein S2, mitochondrial (MRPS2)) at thePDBe-KB.
This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.
