28S ribosomal protein S17, mitochondrial is aprotein that in humans is encoded by theMRPS17gene.[5][6]
Mammalianmitochondrial ribosomal proteins are encoded bynuclear genes and help inprotein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small28S subunit and a large 39S subunit. They have an estimated 75%protein torRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition bysequence homology. This gene encodes a 28S subunit protein that belongs to theribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins.Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq.[6]
Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders".Genomics.77 (1–2):65–70.doi:10.1006/geno.2001.6622.PMID11543634.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome".Genomics.81 (5):468–80.doi:10.1016/S0888-7543(03)00004-1.PMID12706105.
