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MRGPRD

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From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens

MRGPRD

Identifiers

Aliases

MRGPRD, MRGD, TGR7, MAS related GPR family member D

External IDs

OMIM:607231;MGI:3033142;HomoloGene:18893;GeneCards:MRGPRD;OMA:MRGPRD - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)^[1]

Band	11q13.3	Start	68,980,021bp^[1]
Band	11q13.3	End	68,980,986bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F5	Start	144,868,572bp^[2]
Band	7\|7 F5	End	144,877,823bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

testicle

gastric mucosa

muscle layer of sigmoid colon

left uterine tube

popliteal artery

tibial arteries

right coronary artery

cerebellum

smooth muscle tissue

cerebellar cortex

Top expressed in

spinal cord

pons

Gray matter of spinal cord

anterior horn of spinal cord

basal plate

diencephalon

hypothalamus

More reference expression data

BioGPS

n/a

Gene ontology
Molecular function	signal transducer activity G protein-coupled receptor activity
Cellular component	integral component of membrane plasma membrane membrane extracellular space integral component of plasma membrane
Biological process	G protein-coupled receptor signaling pathway signal transduction
Sources:Amigo /QuickGO

Orthologs

Species

Human

Mouse

Entrez


116512


211578

Ensembl


ENSG00000172938


ENSMUSG00000051207

UniProt


Q8TDS7


Q91ZB8

RefSeq (mRNA)


NM_198923


NM_203490

RefSeq (protein)


NP_944605


NP_987075

Location (UCSC)

Chr 11: 68.98 – 68.98 Mb

Chr 7: 144.87 – 144.88 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Mas-related G-protein coupled receptor member D is aprotein that in humans is encoded by theMRGPRDgene.^[5]^[6]^[7]

References

[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000172938 –Ensembl, May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000051207 –Ensembl, May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Dong X, Han S, Zylka MJ, Simon MI, Anderson DJ (Sep 2001)."A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons".Cell.106 (5):619–32.doi:10.1016/S0092-8674(01)00483-4.PMID 11551509.S2CID 14119088.
^Zylka MJ, Dong X, Southwell AL, Anderson DJ (Aug 2003)."Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family".Proc Natl Acad Sci U S A.100 (17):10043–8.Bibcode:2003PNAS..10010043Z.doi:10.1073/pnas.1732949100.PMC 187757.PMID 12909716.
^"Entrez Gene: MRGPRD MAS-related GPR, member D".

Takeda S, Kadowaki S, Haga T, et al. (2002)."Identification of G protein-coupled receptor genes from the human genome sequence".FEBS Lett.520 (1–3):97–101.Bibcode:2002FEBSL.520...97T.doi:10.1016/S0014-5793(02)02775-8.PMID 12044878.S2CID 7116392.
Shinohara T, Harada M, Ogi K, et al. (2004)."Identification of a G protein-coupled receptor specifically responsive to beta-alanine".J. Biol. Chem.279 (22):23559–64.doi:10.1074/jbc.M314240200.PMID 15037633.

Cell surface receptor:G protein-coupled receptors

Class A:Rhodopsin-like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3
Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)
Serotonin	(all but5-HT3)5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)
Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin (1A 1B 1C) TAAR (1 2 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 1 2 FPRL1 OXE Prostaglandin DP (1 2),EP (1 2 3 4),FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid (CB1 CB2,GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide

B/W (1
2)
FF (1
2)
S
Y (1
2
4
5)
Neuromedin (B
U (1
2))
Neurotensin (1
2)

Other

Anaphylatoxin (C3a
C5a (1
2))
Angiotensin (1
2)
Apelin
Bombesin
- BRS3
- GRPR
- NMBR)
- Bradykinin (B1
- B2)
Chemerin
- 1
- 2
Chemokine
Cholecystokinin (A
B)
Endothelin
- A
- B
Formyl peptide (1
2
3)
FSH
Galanin (1
2
3)
Gonadotropin-releasing hormone (1
2)
Ghrelin
Kisspeptin
Luteinizing hormone/choriogonadotropin
MAS (1
1L
D
E
F
G
X1
X2
X3
X4)
Melanocortin (1
2
3
4
5)
MCHR (1
2)
Motilin
Opioid (Delta
Kappa
Mu
Nociceptin &Zeta, but notSigma)
Orexin (1
2)
Oxytocin
Prokineticin (1
2)
Prolactin-releasing peptide
Relaxin (1
2
3
4)
Somatostatin (1
2
3
4
5)
Tachykinin (1
2
3)
Thyrotropin
Thyrotropin-releasing hormone
Urotensin-II
Vasopressin (1A
1B
2)

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR (3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)
Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B:Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)
Other	Calcitonin CALCRL Corticotropin-releasing hormone (1 2) Glucagon (GR GIPR GLP1R GLP2R) Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C:Metabotropic glutamate /pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)