Matrix metalloproteinase-17 (MMP-17) also known asmembrane-type matrix metalloproteinase 4 (MT-MMP 4) is anenzyme that in humans is encoded by theMMP17gene.[5][6]
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown ofextracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. MMP17 andMMP25 are to this day the only knownGPI-anchored membrane-type MMPs, opposite to the more common transmembrane MMPs. The protein activatesMMP2 by cleavage.[6]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Puente XS, Pendas AM, Llano E, Lopez-Otin C (Feb 1999). "Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24".Genomics.54 (3):578–9.doi:10.1006/geno.1998.5564.PMID9878265.
Puente XS, Pendás AM, Llano E, et al. (1996). "Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma".Cancer Res.56 (5):944–9.PMID8640782.
Kolkenbrock H, Essers L, Ulbrich N, Will H (1999). "Biochemical characterization of the catalytic domain of membrane-type 4 matrix metalloproteinase".Biol. Chem.380 (9):1103–8.doi:10.1515/BC.1999.137.PMID10543448.S2CID11192061.
Kinoh H, Hayashita H, Kajita M, et al. (2000). "Assignment of the genes for membrane-type-4 matrix metalloproteinase (Mmp17, MMP17) to mouse chromosome 5, human chromosome band 12q24.3 and membrane-type-5 matrix metalloproteinase (Mmp24, MMP24) to mouse chromosome 2 and human chromosome band 20q11.2→q12, respectively, by radiation hybrid and in situ hybridization".Cytogenet. Cell Genet.87 (1–2):97–8.doi:10.1159/000015402.PMID10640822.S2CID24060884.
Terp GE, Christensen IT, Jørgensen FS (2000). "Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes".J. Biomol. Struct. Dyn.17 (6):933–46.doi:10.1080/07391102.2000.10506582.PMID10949161.S2CID1270176.
Jung M, Römer A, Keyszer G, et al. (2003). "mRNA expression of the five membrane-type matrix metalloproteinases MT1-MT5 in human prostatic cell lines and their down-regulation in human malignant prostatic tissue".Prostate.55 (2):89–98.doi:10.1002/pros.10194.PMID12661033.S2CID21596144.
Gauthier MC, Racine C, Ferland C, et al. (2004). "Expression of membrane type-4 matrix metalloproteinase (metalloproteinase-17) by human eosinophils".Int. J. Biochem. Cell Biol.35 (12):1667–73.doi:10.1016/S1357-2725(03)00136-5.PMID12962706.
