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MLX (gene)

From Wikipedia, the free encyclopedia

Protein-coding gene in the species Homo sapiens
MLX
Identifiers
AliasesMLX, MAD7, MXD7, TCFL4, bHLHd13, MAX dimerization protein, TF4, MAX dimerization protein MLX
External IDsOMIM:602976;MGI:108398;HomoloGene:7969;GeneCards:MLX;OMA:MLX - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for MLX
Genomic location for MLX
Band17q21.2Start42,567,072bp[1]
End42,573,239bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MLX
Genomic location for MLX
Band11|11 DStart100,978,103bp[2]
End100,983,033bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • secondary oocyte

  • parotid gland

  • duodenum

  • mucosa of transverse colon

  • apex of heart

  • mucosa of sigmoid colon

  • jejunal mucosa

  • mucosa of ileum

  • rectum
Top expressed in
  • right kidney

  • granulocyte

  • duodenum

  • jejunum

  • proximal tubule

  • colon

  • yolk sac

  • left colon

  • thymus

  • stomach
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6945

21428

Ensembl

ENSG00000108788

ENSMUSG00000017801

UniProt

Q9UH92

O08609

RefSeq (mRNA)

NM_198205
NM_170607
NM_198204
NM_013383
NM_170608

NM_001159384
NM_001159385
NM_011550

RefSeq (protein)

NP_733752
NP_937847
NP_937848

NP_001152856
NP_001152857
NP_035680

Location (UCSC)Chr 17: 42.57 – 42.57 MbChr 11: 100.98 – 100.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Max-like protein X is aprotein that in humans is encoded by theMLXgene.[5][6]

Function

[edit]

The product of this gene belongs to the family ofbasic helix-loop-helixleucine zipper (bHLH-Zip)transcription factors. These factors formheterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namelyMad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[6]

Interactions

[edit]

MLX (gene) has been shown tointeract withMNT,[7][8]MXD1[7][8] andMLXIPL.[7]

MLX mustdimerize withMondoA[9] or with MLXIPL (carbohydrate-responsive element-binding protein) to regulate target genes.[10]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000108788Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000017801Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Bjerknes M, Cheng H (November 1996). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor".Gene.181 (1–2):7–11.doi:10.1016/S0378-1119(96)00376-9.PMID 8973301.
  6. ^ab"Entrez Gene: MLX MAX-like protein X".
  7. ^abcCairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001)."WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network".Human Molecular Genetics.10 (6):617–27.doi:10.1093/hmg/10.6.617.PMID 11230181.
  8. ^abMeroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?".Oncogene.19 (29):3266–77.doi:10.1038/sj.onc.1203634.PMID 10918583.S2CID 17891130.
  9. ^Kaadige MR, Yang J, Wilde BR, Ayer DE (2015)."MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction".Molecular and Cellular Biology.35 (1):101–110.doi:10.1128/MCB.00636-14.PMC 4295369.PMID 25332233.
  10. ^Song Z, Yang H, Zhou L, Yang F (2019)."Glucose-Sensing Transcription Factor MondoA/ChREBP as Targets for Type 2 Diabetes: Opportunities and Challenges".International Journal of Molecular Sciences.20 (20) E5132.doi:10.3390/ijms20205132.PMC 6829382.PMID 31623194.

Further reading

[edit]

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.

(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous
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