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MK-9470

From Wikipedia, the free encyclopedia

MK-9470
[18F]-MK-9470
Names
Preferred IUPAC name
N-[(2S,3S)-3-(3-Cyanophenyl)-4-[4-(2-fluoroethoxy)phenyl]butan-2-yl]-2-methyl-2-(5-methylpyridin-2-yl)oxypropanamide
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C29H32FN3O3/c1-20-8-13-27(32-19-20)36-29(3,4)28(34)33-21(2)26(24-7-5-6-23(16-24)18-31)17-22-9-11-25(12-10-22)35-15-14-30/h5-13,16,19,21,26H,14-15,17H2,1-4H3,(H,33,34)/t21-,26+/m0/s1
    Key: JWBGLSNXGRDLKH-HFZDXXHNBD
  • [18F]: InChI=1S/C29H32FN3O3/c1-20-8-13-27(32-19-20)36-29(3,4)28(34)33-21(2)26(24-7-5-6-23(16-24)18-31)17-22-9-11-25(12-10-22)35-15-14-30/h5-13,16,19,21,26H,14-15,17H2,1-4H3,(H,33,34)/t21-,26+/m0/s1/i30-1
    Key: XIYPJXKEMLKFMD-MSNFMOCCSA-N
  • CC1=CN=C(C=C1)OC(C)(C)C(=O)N[C@@H](C)[C@@H](CC2=CC=C(C=C2)OCCF)C3=CC=CC(=C3)C#N
  • [18F]: [C@@H](CC1=CC=C(OCC[18F])C=C1)([C@@H](NC(C(OC2=CC=C(C)C=N2)(C)C)=O)C)C3=CC(C#N)=CC=C3
Properties
C29H32FN3O3
Molar mass489.591 g·mol−1
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)
Chemical compound

MK-9470 is a synthetic compound which binds to theCB1 cannabinoid receptor and functions as aninverse agonist. The18F-labeled version, [18F]-MK-9470, is used in research as apositron emission tomography (PET) tracer for brain imaging of the CB1 receptor.[1]

References

[edit]
  1. ^Burns HD, Van Laere K, Sanabria-Bohórquez S, Hamill TG, Bormans G, Eng WS, et al. (June 2007)."[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor".Proceedings of the National Academy of Sciences of the United States of America.104 (23):9800–9805.Bibcode:2007PNAS..104.9800B.doi:10.1073/pnas.0703472104.PMC 1877985.PMID 17535893.
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