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MK-4409

From Wikipedia, the free encyclopedia
Chemical compound
Pharmaceutical compound
MK-4409
Clinical data
ATC code
  • None
Legal status
Legal status
Identifiers
  • 2-[5-[5-(5-Chloropyridin-2-yl)sulfanyl-2-(4-fluorophenyl)-1,3-oxazol-4-yl]pyridin-2-yl]propan-2-ol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC22H17FN3O2S
Molar mass406.46 g·mol−1
3D model (JSmol)
  • c3nc(C(O)(C)C)ccc3-c1nc(-c4ccc(F)cc4)oc1Sc(nc2)ccc2Cl
  • InChI=1S/C22H17ClFN3O2S/c1-22(2,28)17-9-5-14(11-25-17)19-21(30-18-10-6-15(23)12-26-18)29-20(27-19)13-3-7-16(24)8-4-13/h3-12,28H,1-2H3
  • Key:DBZMCSVIITXLCC-UHFFFAOYSA-N

MK-4409 is an experimental drug which acts as a potent and selective inhibitor of the enzymefatty acid amide hydrolase (FAAH), with an IC50 of 11 nM, and bothanalgesic andantiinflammatory effects in animal studies. It was studied for the treatment ofneuropathic pain and progressed to early stage humanclinical trials by 2009.[1][2]

See also

[edit]

References

[edit]
  1. ^Chobanian HR, Guo Y, Liu P, Chioda MD, Fung S, Lanza TJ, et al. (June 2014)."Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain".ACS Medicinal Chemistry Letters.5 (6):717–21.doi:10.1021/ml5001239.PMC 4060928.PMID 24944750.
  2. ^Merck (15 October 2009)."Merck Pipeline, Oct 2009"(PDF).Merck. Archived fromthe original(PDF) on 20 October 2016. Retrieved18 January 2016.

External links

[edit]
  • "MK 4409".Adis Insight. Springer Nature Switzerland AG.
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