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MIT Jameel Clinic

From Wikipedia, the free encyclopedia
MIT Jameel Clinic
Established2018
Field of research
Artificial intelligence and health
DirectorsRegina Barzilay
James J. Collins
Dimitris Bertsimas
Chairs
Dan Huttenlocher
Phil Sharp
CampusMassachusetts Institute of Technology
AffiliationsMIT Schwarzman College of Computing
Phil Sharp
Websitejclinic.mit.edu

TheMIT Abdul Latif Jameel Clinic for Machine Learning in Health (commonly,MIT Jameel Clinic; previously, J-Clinic) is aresearch center at theMassachusetts Institute of Technology (MIT) in the field ofartificial intelligence (AI) and health sciences, including disease detection,drug discovery, and the development ofmedical devices. The MIT Jameel Clinic also supports the commercialization of solutions through grant funding, and has partnered with pharmaceutical companies, likeTakeda andSanofi, and philanthropies, likeCommunity Jameel andWellcome Trust, to forge collaborations between research and development functions and MIT researchers.[1][2]

Co-founded in 2018 by MIT and Community Jameel,[3] the MIT Jameel Clinic is housed in theMIT Schwarzman College of Computing. The mission of the Jameel Clinic is to "revolutionize the prevention, detection, and treatment of disease", and it describes itself as "the epicenter of AI and healthcare at MIT".[4]

The MIT Jameel Clinic is known for using AI for the discovery of the antibioticshalicin andabaucin, and the development of early cancer detection platforms Mirai forbreast cancer, and Sybil forlung cancer.

History

[edit]

On September 17, 2018, the MIT Jameel Clinic was co-founded by MIT and Community Jameel, an organisation of the Jameel family, owners of theAbdul Latif Jameel business.[5] The launch took place at a signing ceremony at MIT with MIT PresidentL. Rafael Reif, and Fady Jameel andHassan Jameel, then-presidents of Community Jameel.[3][6] The MIT Jameel Clinic is the fourth major collaboration between MIT and Community Jameel, after theAbdul Latif Jameel Poverty Action Lab, the MIT Abdul Latif Jameel Water and Food Systems Lab, and the MIT Abdul Latif Jameel World Education Lab.[3]

MIT-Takeda Program

[edit]

On January 6, 2020, theMIT School of Engineering andTakeda, the pharmaceutical company, announced a new funding program to support research and education in AI and health. The MIT-Takeda Program is housed in the MIT Jameel Clinic. The steering committee for the program is led by ProfessorAnantha P. Chandrakasan, Dean of the School of Engineering, and Anne Heatherington, senior vice president and head of Data Sciences Institute (DSI) at Takeda.[1][7][8]

Discovery of halicin

[edit]

On February 19, 2020, the MIT Jameel Clinic's faculty leads for AI and life sciences, ProfessorRegina Barzilay and ProfessorJim Collins, published a paper inCell confirming the discovery—for the first time bydeep learning—ofhalicin, the first newantibiotic compound for 30 years, which kills over 35 powerfulbacteria, includingantimicrobial-resistanttuberculosis, the superbugC. difficile, and two of theWorld Health Organization's top-three most deadly bacteria.[9][10][11][12][13]

AI Cures initiative

[edit]

In 2020, during theCOVID-19 pandemic, the MIT Jameel Clinic launched theAI Cures initiative to apply AI techniques to the discovery of effectivetherapeutics for the disease, and the development of medical devices. The AI Cures initiative is in partnership with thePatrick J. McGovern Foundation, theDefense Advanced Research Projects Agency (DARPA), and theWalter Reed Army Institute of Research (WRAIR).[14]

In September and October 2020, the MIT Jameel Clinic convened two conferences, on data-driven clinical solutions for COVID-19, and on drug discovery.[15][16]

Audacious Project award

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In June 2020,The Audacious Project (formerly theTED Prize), housed atTED and supported byThe Bridgespan Group, selected Professor Collins and an MIT Jameel Clinic team, including Professor Barzilay, for funding. Building on the halicin discovery, the Audacious Project funding will support the MIT Jameel Clinic's response to the antibiotic resistance crisis through the development of new classes of antibiotics to protect patients against some of the world's deadliest bacterial pathogens.[17][18]

Ragon Institute collaboration

[edit]

In July 2021, a gift from Mark Schwartz enabled the MIT Jameel Clinic to partner with theRagon Institute (a collaboration betweenMassachusetts General Hospital,Harvard University and MIT) and the MIT Schwarzman College of Computing to create a collaborative initiative for AI andimmunology.[19]

Jameel Clinic AI Hospital Network

[edit]

With a GBP 3.5m grant fromWellcome Trust, the MIT Jameel Clinic is teaming up with hospitals around the globe to bring AI into mainstream healthcare.[20][21][22] To date, the network has extended to 41 hospitals in 13 countries.[22] In providing free access to AI tools, the Jameel Clinic aims to contribute the expertise of its researchers to empower healthcare systems by accelerating the mainstream usage of AI tools on a global scale.[22]

Discovery of abaucin

[edit]

On 25 May 2023, the MIT Jameel Clinic's faculty leads for life sciences, Jim Collins, and for AI, Regina Barzilay, and colleagues published a paper inNature Chemical Biology announcing the deep learning-guided discover ofabaucin, an antibiotic targetingAcinetobacter baumannii, one of the WHO's top-three deadliest bacteria in the world.[23][24][25]

Faculty and governance

[edit]

Leadership

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The MIT Jameel Clinic leadership comprises three faculty leads:

The faculty leads are supported by the Jameel Clinic staff, and coordinate with the Dean of the MIT Schwarzman College of Computing,Daniel P. Huttenlocher.[26][27]

Advisory board

[edit]

The MIT Jameel Clinic is supported by anadvisory board, chaired by ProfessorPhil Sharp, winner of the 1993Nobel Prize in Physiology or Medicine,Institute Professor, former director of theKoch Institute for Integrative Cancer Research and theMcGovern Institute for Brain Research, and co-founder ofBiogen.[28]

Other members of the advisory board are:

Former members of the advisory board include:

References

[edit]
  1. ^ab"MIT School of Engineering and Takeda join to advance research in artificial intelligence and health".MIT News | Massachusetts Institute of Technology. Retrieved2020-11-12.
  2. ^"Jameel Clinic teams up with Sanofi on AI and machine learning".Drug Discovery News. Retrieved2021-01-27.
  3. ^abc"Abdul Latif Jameel Clinic for Machine Learning in Health at MIT aims to revolutionize disease prevention, detection, and treatment".MIT News | Massachusetts Institute of Technology. Retrieved2020-11-12.
  4. ^"Jameel Clinic | AI & Healthcare at MIT".Jameel Clinic. Retrieved2020-11-12.
  5. ^"Community Jameel | Innovating for a better future".Community Jameel | Innovating for a better future. Retrieved2020-11-12.
  6. ^"New Jameel Clinic to harness machine learning tech".Arab News. 2018-09-25. Retrieved2020-11-12.
  7. ^analytica, TOKYO (2020-01-07)."武田薬品とMITがAI研究を推進するプログラムを発表 | 医療とAIのニュース・最新記事 - The Medical AI Times".The AI Times (in Japanese). Retrieved2020-11-12.
  8. ^"MIT, Takeda collaborate on new healthcare AI applications".Healthcare IT News. 2020-01-06. Retrieved2020-11-12.
  9. ^Stokes, Jonathan M.; Yang, Kevin; Swanson, Kyle; Jin, Wengong; Cubillos-Ruiz, Andres; Donghia, Nina M.; MacNair, Craig R.; French, Shawn; Carfrae, Lindsey A.; Bloom-Ackermann, Zohar; Tran, Victoria M. (2020-02-20)."A Deep Learning Approach to Antibiotic Discovery".Cell.180 (4): 688–702.e13.doi:10.1016/j.cell.2020.01.021.ISSN 0092-8674.PMC 8349178.PMID 32084340.
  10. ^"Artificial Intelligence Yields New Antibiotic".The MIT Campaign for a Better World. Retrieved2020-11-12.
  11. ^Murgia, Madhumita (February 20, 2020)."AI discovers antibiotics to treat drug-resistant diseases".Financial Times. Retrieved12 November 2020.
  12. ^"Powerful antibiotic discovered using machine learning for first time".the Guardian. 2020-02-20. Retrieved2020-11-12.
  13. ^Marchant, Jo (2020-02-20)."Powerful antibiotics discovered using AI".Nature.doi:10.1038/d41586-020-00018-3.PMID 33603175.S2CID 214135545.
  14. ^"Home".AI Cures. Retrieved2020-11-12.
  15. ^"Events".Jameel Clinic. Retrieved2020-11-12.
  16. ^"AI Cures: data-driven clinical solutions for Covid-19".MIT News | Massachusetts Institute of Technology. Retrieved2020-11-12.
  17. ^"Jim Collins receives funding to harness AI for drug discovery".MIT News | Massachusetts Institute of Technology. Retrieved2020-11-12.
  18. ^재발행, Plato에 의해."짐 콜린스, 약물 발견을 위해 AI를 활용하기위한 자금 지원 |" (in Korean). Retrieved2020-11-12.
  19. ^"Supercharging Immunology Research".Ragon Institute of MGH, MIT and Harvard. Retrieved2021-08-30.
  20. ^"222396/Z/21/Z".Wellcome. Retrieved2023-12-16.
  21. ^"The Potential of Artificial Intelligence to Bring Equity in Health Care".MIT for a Better World. Retrieved2023-12-16.
  22. ^abc"Hospital Network – MIT Jameel Clinic". Retrieved2023-12-16.
  23. ^Stokes, Jonathan M.; Collins, James J.; Liu, Gary; Catacutan, Denise B.; Rathod, Khushi; Swanson, Kyle; Jin, Wengong; Mohammed, Jody C.; Chiappino-Pepe, Anush; Syed, Saad A.; Fragis, Meghan; Rachwalski, Kenneth; Magolan, Jakob; Surette, Michael G.; Coombes, Brian K.; Jaakola, Tommi; Barzilay, Regina (25 May 2023)."Deep learning-guided discovery of an antibiotic targeting Acinetobacter baumannii".Nature Chemical Biology.2023 (11):1342–1350.doi:10.1038/s41589-023-01349-8. Retrieved28 May 2023.
  24. ^Trafton, Anne (25 May 2023)."Using AI, scientists find a drug that could combat drug-resistant infections".MIT News. Retrieved28 May 2023.
  25. ^Gallagher, James (25 May 2023)."New superbug-killing antibiotic discovered using AI".BBC. Retrieved28 May 2023.
  26. ^ab"People".Jameel Clinic. Archived fromthe original on 2021-11-30. Retrieved2020-11-12.
  27. ^"Regina Barzilay, James Collins, and Phil Sharp join leadership of new effort on machine learning in health".MIT News | Massachusetts Institute of Technology. Retrieved2020-11-12.
  28. ^"Phillip A. Sharp".MIT Department of Biology. Retrieved2020-11-12.
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