Melanotransferrin is aprotein that in humans is encoded by theMFI2gene. MFI2 has also recently been designatedCD228 (cluster of differentiation 228).
The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants.[5] It is part ofneural crest tissue, often present inmelanotic neuroectodermal tumor of infancy.
Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis".Oncogene.26 (42):6113–24.doi:10.1038/sj.onc.1210442.PMID17452986.S2CID35884470.
Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study".Liver.9 (2):110–9.doi:10.1111/j.1600-0676.1989.tb00387.x.PMID2540389.
Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen".Hum. Genet.72 (4):294–6.doi:10.1007/BF00290951.PMID3754536.S2CID38961040.
Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium".Brain Res.712 (1):117–21.doi:10.1016/0006-8993(96)88505-2.PMID8705293.S2CID45470799.
Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell".Eur. J. Biochem.267 (5):1290–8.doi:10.1046/j.1432-1327.2000.01079.x.PMID10691965.
