This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-likehomeobox-containingtranscription factor genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[6] MEOX2 has been implicated in the initiation of tumors in glioma.[7] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.[8][9]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^LePage DF, Altomare DA, Testa JR, Walsh K (December 1994). "Molecular cloning and localization of the human GAX gene to 7p21".Genomics.24 (3):535–540.doi:10.1006/geno.1994.1663.PMID7713505.
^Peralta-Arrieta I, Trejo-Villegas OA, Armas-López L, Ceja-Rangel HA, Ordóñez-Luna MD, Pineda-Villegas P, et al. (January 2022). "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer".European Journal of Cancer.160:189–205.doi:10.1016/j.ejca.2021.10.032.PMID34844838.
Grigoriou M, Kastrinaki MC, Modi WS, Theodorakis K, Mankoo B, Pachnis V, et al. (April 1995). "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3".Genomics.26 (3):550–555.doi:10.1016/0888-7543(95)80174-K.PMID7607679.
Reardon W, McManus SP, Summers D, Winter RM (October 1993). "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2".American Journal of Medical Genetics.47 (5):633–636.doi:10.1002/ajmg.1320470510.PMID8266988.
Quinn LM, Latham SE, Kalionis B (2000). "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta".Placenta. 21 Suppl A:S50 –S54.doi:10.1053/plac.1999.0514.PMID10831122.
Gorski DH, Leal AJ (May 2003). "Inhibition of endothelial cell activation by the homeobox gene Gax".The Journal of Surgical Research.111 (1):91–99.doi:10.1016/S0022-4804(03)00042-8.PMID12842453.
Wu Z, Guo H, Chow N, Sallstrom J, Bell RD, Deane R, et al. (September 2005). "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease".Nature Medicine.11 (9):959–965.doi:10.1038/nm1287.PMID16116430.S2CID12998034.
Lin J, Friesen MT, Bocangel P, Cheung D, Rawszer K, Wigle JT (July 2005). "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10".Molecular and Cellular Biochemistry.275 (1–2):75–84.doi:10.1007/s11010-005-0823-3.PMID16335786.S2CID30515981.
