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MDMB-5Br-INACA

From Wikipedia, the free encyclopedia
Chemical compound

Pharmaceutical compound
MDMB-5Br-INACA
Legal status
Legal status
Identifiers
  • methyl (2S)-2-[(5-bromo-1H-indazole-3-carbonyl)amino]-3,3-dimethylbutanoate
PubChemCID
ChemSpider
UNII
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Chemical and physical data
FormulaC15H18BrN3O3
Molar mass368.231 g·mol−1
3D model (JSmol)
  • O=C(OC)[C@@H](NC(=O)c1n[NH]c2ccc(Br)cc21)C(C)(C)C
  • InChI=1S/C15H18BrN3O3/c1-15(2,3)12(14(21)22-4)17-13(20)11-9-7-8(16)5-6-10(9)18-19-11/h5-7,12H,1-4H3,(H,17,20)(H,18,19)/t12-/m1/s1
  • Key:QGEVEXPJOKFMAN-GFCCVEGCSA-N

MDMB-5Br-INACA is anindazole-3-carboxamide derivative which has been sold as adesigner drug.[2] Surprisingly it has been reported to produce psychoactive activity despite the lack of a "tail" group at the indazole 1-position, but is likely of relatively low potency as a CB1 agonist and has been encountered being misrepresented as other illicit drugs such asMDMA.[3][4] This reported psychoactive activity has been limitedly reported on but could be related to activity beyond the cannabinoid receptors due to vague structural relation to compounds like1Z2MAP1O.

Use as a precursor

[edit]

MDMB-5Br-INACA is believed to be used as a precursor in the synthesis of synthetic cannabinoids. It has been sold online as a "chemistry kit" with other compounds required to complete the reaction. This reaction would complete MDMB-5Br-INACA by giving it a "tail" group required for high cannabinoid activity. Other precursors lacking a tail chain have also been marketed such as (ADB-5-Br-INACA),[5] (CH-IATA), (ADB-IACA), and (ADB-5’Br-EZO-CA). This may be due to increasing legality changes worldwide on synthetic cannabinoids.[6][7]

Legality

[edit]

In the United States, MDMB-5Br-INACA is unscheduled at the federal level as of May 22nd, 2023.

North Dakota has placed MDMB-5Br-INACA (along with ADB-5'Br-BINACA,ADB-5'Br-BUTINACA and ADB-5-Br-INACA) into Schedule I on 04/27/2023.[8]

See also

[edit]

References

[edit]
  1. ^Anvisa (2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União (published 2023-07-25).Archived from the original on 2023-08-27. Retrieved2023-08-27.
  2. ^"CFSRE Analysis Report"(PDF).Indianapolis-Marion County Forensic Services Agency. 17 May 2022.
  3. ^"Drug testers warn of new synthetic cannabinoid being sold as MDMA".New Zealand Herald. 5 August 2022.
  4. ^Deventer MH, Persson M, Norman C, Liu H, Connolly MJ, Daéid NN, et al. (October 2023). "In vitro cannabinoid activity profiling of generic ban-evading brominated synthetic cannabinoid receptor agonists and their analogs".Drug Testing and Analysis.16 (6):616–628.doi:10.1002/dta.3592.PMID 37903509.S2CID 264671035.
  5. ^Choi H, Kim S, Jang H, Kim HJ, Choe S (September 2022). "Identification of a novel bromoindazole synthetic cannabinoid analogue in seized e-cigarette liquid: ADB-BRINACA".Forensic Science International.338 111385.doi:10.1016/j.forsciint.2022.111385.PMID 35863161.
  6. ^"Cumyl-PeGaClone and other recently encountered synthetic cannabinoid receptor agonists. A review of the evidence on their use and harms"(PDF).Advisory Council on the Misuse of Drugs. 2022.
  7. ^Andrews R, Jorge R, Christie R, Gallegos A (April 2023)."From JWH-018 to OXIZIDS: Structural evolution of synthetic cannabinoids in the European Union from 2008 to present day".Drug Testing and Analysis.15 (4):378–387.doi:10.1002/dta.3422.PMID 36507715.
  8. ^"AN ACT to amend and reenact sections 19-03.1-05, 19-03.1-11, and 19-03.1-13 of the North Dakota Century Code, relating to the scheduling of controlled substances; and to declare an emergency"(PDF).Sixty-eighth Legislative Assembly of North Dakota in Regular Session. 3 January 2023.
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