Mitogen-activated protein kinase 4 is anenzyme that in humans is encoded by theMAPK4gene.[5][6]
Mitogen-activated protein kinase 4 is a member of themitogen-activated protein kinase family. Tyrosine kinase growth factorreceptors activate mitogen-activated protein kinases which then translocate into thenucleus where itphosphorylates nuclear targets.[6]
The Arabidopsis MAPK4 is important in signalling[7]
Mechanistically, MAPK4 directly bound and activated AKT by phosphorylation of the activation loop at threonine 308. It also activated mTORC2 to phosphorylate AKT at serine 473 for full activation. MAPK4 overexpression induced oncogenic outcomes, including transforming prostate epithelial cells into anchorage-independent growth, and MAPK4 knockdown inhibited cancer cell proliferation, anchorage-independent growth, and xenograft growth.[8]
Sun M, Wei Y, Yao L, Xie J, Chen X, Wang H, et al. (February 2006). "Identification of extracellular signal-regulated kinase 3 as a new interaction partner of cyclin D3".Biochemical and Biophysical Research Communications.340 (1):209–14.doi:10.1016/j.bbrc.2005.12.003.PMID16360641.
