Protein-coding gene in the species Homo sapiens
Transcription factor Maf , also known asproto-oncogene c-Maf orV-maf musculoaponeurotic fibrosarcoma oncogene homolog , is atranscription factor that in humans is encoded by theMAF gene .[ 5] [ 6]
One type,MafA , also known asRIPE3b1 ,[ 7] pancreatic development , as well asinsulin gene transcription.[ 8]
MAF has been shown tointeract with:
^a b c GRCh38: Ensembl release 89: ENSG00000178573 –Ensembl , May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000055435 –Ensembl , May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)" .^ Nishizawa M, Kataoka K, Goto N, Fujiwara KT, Kawai S (Oct 1989)."v-maf, a viral oncogene that encodes a "leucine zipper" motif" .Proceedings of the National Academy of Sciences of the United States of America .86 (20):7711– 5.Bibcode :1989PNAS...86.7711N .doi :10.1073/pnas.86.20.7711 PMC 298140 PMID 2554284 . ^ Olbrot M, Rud J, Moss LG, Sharma A (May 2002)."Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA" .Proceedings of the National Academy of Sciences of the United States of America .99 (10):6737– 42.Bibcode :2002PNAS...99.6737O .doi :10.1073/pnas.102168499 PMC 124472 PMID 12011435 . ^ Melloul D, Marshak S, Cerasi E (Mar 2002)."Regulation of insulin gene transcription" .Diabetologia .45 (3):309– 26.doi :10.1007/s00125-001-0728-y PMID 11914736 . ^a b Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002)."CREB-binding protein/p300 co-activation of crystallin gene expression" .The Journal of Biological Chemistry .277 (27):24081– 9.doi :10.1074/jbc.M201821200 PMID 11943779 . ^ Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998)."c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation" .Molecular and Cellular Biology .18 (5):2729– 37.doi :10.1128/MCB.18.5.2729 .PMC 110652 PMID 9566892 . ^ Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002)."A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene" .The Journal of Biological Chemistry .277 (52):50668– 75.doi :10.1074/jbc.M206544200 PMID 12381733 . Kerppola TK, Curran T (Mar 1994). "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun".Oncogene .9 (3):675– 84.PMID 8108109 . Kurschner C, Morgan JI (Feb 1997). "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity".Biochemical and Biophysical Research Communications .231 (2):333– 9.Bibcode :1997BBRC..231..333K .doi :10.1006/bbrc.1997.6097 .PMID 9070273 . Hedge SP, Kumar A, Kurschner C, Shapiro LH (May 1998)."c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation" .Molecular and Cellular Biology .18 (5):2729– 37.doi :10.1128/MCB.18.5.2729 .PMC 110652 PMID 9566892 . Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried T, Kuehl WM (Jun 1998). "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma".Blood .91 (12):4457– 63.doi :10.1182/blood.V91.12.4457 .PMID 9616139 .S2CID 14835515 . Christodoulopoulos P, Cameron L, Nakamura Y, Lemière C, Muro S, Dugas M, Boulet LP, Laviolette M, Olivenstein R, Hamid Q (Apr 2001)."TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression" .The Journal of Allergy and Clinical Immunology .107 (4):586– 91.doi :10.1067/mai.2001.114883 PMID 11295643 . Jamieson RV, Perveen R, Kerr B, Carette M, Yardley J, Heon E, Wirth MG, van Heyningen V, Donnai D, Munier F, Black GC (Jan 2002)."Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma" .Human Molecular Genetics .11 (1):33– 42.doi :10.1093/hmg/11.1.33 PMID 11772997 . Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (Jul 2002)."CREB-binding protein/p300 co-activation of crystallin gene expression" .The Journal of Biological Chemistry .277 (27):24081– 9.doi :10.1074/jbc.M201821200 PMID 11943779 . Dhakshinamoorthy S, Jaiswal AK (Aug 2002)."c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction" .Oncogene .21 (34):5301– 12.doi :10.1038/sj.onc.1205642 PMID 12149651 . Cousins DJ, Lee TH, Staynov DZ (Sep 2002)."Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines" .Journal of Immunology .169 (5):2498– 506.doi :10.4049/jimmunol.169.5.2498 PMID 12193719 . Huang W, Lu N, Eberspaecher H, De Crombrugghe B (Dec 2002)."A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene" .The Journal of Biological Chemistry .277 (52):50668– 75.doi :10.1074/jbc.M206544200 PMID 12381733 . DePianto DJ, Blankenship TN, Hess JF, FitzGerald PG (Jun 2003). "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice".Molecular Vision .9 :288– 94.PMID 12835653 . Grimbert P, Valanciute A, Audard V, Pawlak A, Le gouvelo S, Lang P, Niaudet P, Bensman A, Guellaën G, Sahali D (Sep 2003)."Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization" .The Journal of Experimental Medicine .198 (5):797– 807.doi :10.1084/jem.20030566 .PMC 1865475 PMID 12939343 . Valanciuté A, le Gouvello S, Solhonne B, Pawlak A, Grimbert P, Lyonnet L, Hue S, Lang P, Remy P, Salomon R, Bensman A, Guellaën G, Sahali D (Jan 2004)."NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome" .Journal of Immunology .172 (1):688– 98.doi :10.4049/jimmunol.172.1.688 PMID 14688382 . Rasmussen T, Knudsen LM, Dahl IM, Johnsen HE (Oct 2003). "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance".Leukemia & Lymphoma .44 (10):1761– 6.doi :10.1080/1042819031000111035 .PMID 14692531 .S2CID 3191366 . Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM (Feb 2004)."Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma" .Cancer Cell .5 (2):191– 9.doi :10.1016/S1535-6108(04)00019-4 PMID 14998494 . Cao S, Liu J, Song L, Ma X (Mar 2005)."The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages" .Journal of Immunology .174 (6):3484– 92.doi :10.4049/jimmunol.174.6.3484 .PMC 2955976 PMID 15749884 . Morito N, Yoh K, Fujioka Y, Nakano T, Shimohata H, Hashimoto Y, Yamada A, Maeda A, Matsuno F, Hata H, Suzuki A, Imagawa S, Mitsuya H, Esumi H, Koyama A, Yamamoto M, Mori N, Takahashi S (Jan 2006)."Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human" .Cancer Research .66 (2):812– 9.doi :10.1158/0008-5472.CAN-05-2154 PMID 16424013 . Vanita V, Singh D, Robinson PN, Sperling K, Singh JR (Mar 2006). "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family".American Journal of Medical Genetics Part A .140 (6):558– 66.doi :10.1002/ajmg.a.31126 .PMID 16470690 .S2CID 13734492 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
