| Flu_M1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 influenza virus m1 protein | |||||||||
| Identifiers | |||||||||
| Symbol | Flu_M1 | ||||||||
| Pfam | PF00598 | ||||||||
| InterPro | IPR001561 | ||||||||
| SCOP2 | 1aa7 /SCOPe /SUPFAM | ||||||||
| OPM superfamily | 42 | ||||||||
| OPM protein | 1aa7 | ||||||||
| |||||||||
TheM1 protein is amatrix protein of theinfluenzavirus. It forms a coat inside theviral envelope. This is a bifunctional membrane/RNA-binding protein that mediates theencapsidation ofnucleoprotein cores into themembrane envelope. It is therefore required that M1binds bothmembrane and RNA simultaneously.[1]
The M1 protein binds to the viralRNA. The binding is not specific to any RNA sequence, and is performed via apeptide sequence rich inbasicamino acids.[citation needed]
It also has multiple regulatory functions, performed by interaction with the components of the host cell. The mechanisms regulated include a role in the export of the viralribonucleoproteins from the hostcell nucleus, inhibition of viraltranscription, and a role in the virus assembly andbudding. The protein was found to undergophosphorylation in the host cell.[citation needed]
The M1 protein forms a layer under the patches of host cell membrane that are rich with the viralhemagglutinin,neuraminidase andM2transmembrane proteins, and facilitatesbudding of the mature viruses.[citation needed]
M1 consists of twodomains connected by a linkersequence. The N-terminaldomain has a multi-helicalstructure that can be divided into two subdomains.[2] The C-terminal domain also containsalpha-helicalstructure.