 | This article includes alist of references,related reading, orexternal links,but its sources remain unclear because it lacksinline citations. Please helpimprove this article byintroducing more precise citations.(April 2020) (Learn how and when to remove this message) |
| Lysine—tRNA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.1.1.6 | ||||||||
| CAS no. | 9031-26-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO /QuickGO | ||||||||
| |||||||||
Inenzymology, alysine—tRNA ligase (EC6.1.1.6) is anenzyme thatcatalyzes thechemical reaction
The 3substrates of this enzyme areATP,L-lysine, andtRNA(Lys), whereas its 3products areAMP,diphosphate, andL-lysyl-tRNA(Lys).
This enzyme participates in 3metabolic pathways:lysine biosynthesis,aminoacyl-trna biosynthesis, andamyotrophic lateral sclerosis (als).
This enzyme belongs to the family ofligases, to be specific, those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. Thesystematic name of this enzyme class is L-lysine:tRNALys ligase (AMP-forming). Other names in common use include lysyl-tRNA synthetase, lysyl-transfer ribonucleate synthetase, lysyl-transfer RNA synthetase, L-lysine-transfer RNA ligase, lysine-tRNA synthetase, and lysine translase.
