LSM-775 is lesspotent thanLSD but is reported to have some LSD-like effects at doses ranging from 75 to 1,000μgorally and a shorterduration.[1][4][3] It may only produce weak or thresholdpsychedelic effects in humans.[4] There have been said to be fewer signs ofcardiovascularstimulation andperipheraltoxicity with LSM-775 compared to LSD.[1] On the other hand, more recent reports suggest that LSM-75 produces considerablenausea and feelings oflethargy andsedation.[4]
^abcdefghiBrandt SD, Kavanagh PV, Twamley B, Westphal F, Elliott SP, Wallach J, et al. (February 2018)."Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775)".Drug Testing and Analysis.10 (2):310–322.doi:10.1002/dta.2222.PMC6230476.PMID28585392.Although lysergic acid morpholide (LSM-775) appeared on the NPS market in 2013, there is disagreement in the literature regarding the potency and psychoactive properties of LSM-775 in humans. [...] The preparation of LSM-775 was first described in the 1950s by Stoll and Hoffmann18 and several other routes have also been reported.19–21 There is disagreement in the literature regarding the potency and psychoactive properties of LSM-775 in humans. Goggerty and Dille reported that 75 µg LSM-775 produced approximately the same response as 50 µg LSD in two subjects, although LSM-775 had a shorter duration of action than LSD.22 In a blinded experiment conducted by Abramson, two subjects administered 150 µg LSM-775 estimated that they had received 25–35 µg LSD, whereas a third subject estimated that they had received a placebo.23 Isbell et al. found that higher doses of LSM-775 (4.5 and 9 µg/kg) produced effects roughly equivalent to a threshold dose of LSD, but with a shorter duration.24,25 One potential explanation for these discrepant findings is that LSM-775 may be capable of producing only a threshold psychedelic response. However, the methodological weaknesses in early human studies with LSM-775 make interpretation challenging. [...] LSM-775 has been distributed by online vendors as an NPS. According to reports on Internet discussion forums and websites, 1 mg LSM-775 mimics the effects produced by low doses of LSD, but also induces considerable nausea and feelings of lethargy and sedation.57 Similarly, when tested in preliminary clinical trials, LSM-775 was only capable of producing a weak psychedelic response, similar to low or threshold doses of LSD.
^Nichols DE (2001)."LSD and Its Lysergamide Cousins"(PDF).The Heffter Review of Psychedelic Research.2.Heffter Research Institute:80–87.ISSN1534-9640.The two ethyl groups [of LSD] were incorporated into ring structures such as the pyrrolidide, piperidide, and morpholide, shown above, but these also had reduced anti-serotonin and psychedelic effects (Cerletti and Doepfner 1958). Although the morpholide had less than one-tenth of the potency of LSD in blocking the action of serotonin, it did however have nearly 75% of the potency of LSD as a psychedelic (Gogerty and Dille 1957).
