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| Names | |
|---|---|
| IUPAC name 1-[2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-3-(2,6-difluorobenzoyl)urea | |
| Other names N-[[[2,5-Dichloro-4-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]amino]carbonyl]-2,6-difluorobenzamide Fluphenacur U.S. EPA PC Code: 118205 | |
| Identifiers | |
3D model (JSmol) | |
| ChEBI | |
| ChEMBL | |
| ChemSpider |
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| ECHA InfoCard | 100.101.025 |
| KEGG |
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| UNII | |
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| Properties | |
| C17H8Cl2F8N2O3 | |
| Molar mass | 511.15 g·mol−1 |
| Melting point | 174 °C (345 °F; 447 K) |
| Pharmacology | |
| QP53BC01 (WHO) | |
Except where otherwise noted, data are given for materials in theirstandard state (at 25 °C [77 °F], 100 kPa). | |
Lufenuron is theactive ingredient in theveterinaryflea control medication program, and one of the two active ingredients in the flea,heartworm, andanthelmintic medicinemilbemycin oxime/lufenuron (Sentinel).
Lufenuron is stored in the animal's bodyfat and transferred to adult fleas through the host's blood when they feed. Adult fleas transfer it to their growing eggs through their blood, and to hatched larvae feeding on their excrement. It does not kill adult fleas.[citation needed]
Lufenuron, abenzoylurea pesticide, inhibits the production ofchitin in insects. Without chitin, a larval flea will never develop a hard outer shell (exoskeleton). With its inner organs exposed to air, the insect dies from dehydration soon after hatching or molting (shedding its old, smaller shell).[citation needed]
Lufenuron is also used to fightfungal infections, since fungus cell walls are about one third chitin.[1]
Lufenuron is also sold as an agricultural pesticide for use againstlepidopterans, eriophyidmites, andwestern flower thrips. It is an effective antifungal in plants.[2]
Lufenuron, a chitin synthesis inhibitor, is an effective agent against lepidopteran members in crops, eriophid mites and western flower thrips. In non-crop situations too, lufenuron is effective against fleas on animals and on cockroaches in households. This chemical also acts as an anti-fungal agent in plants. ... According to the WHO, lufenuron is a Class III toxin (slightly hazardous). It is safe on mammals, since it is not broken down by the liver or kidneys.
